Human exposure to selected animal neurocarcinogens: a biomarker-based assessment and implications for brain tumor epidemiology.

Journal Article (Journal Article;Review)

This review is based on the proceedings from the Second Lebow Conference, held in Chicago in 2007. The conference concentrated on developing a framework for innovative studies in the epidemiology of environmental exposures, focusing specifically on the potential relationship with brain tumors. Researchers with different perspectives, including toxicology, pharmacokinetics, and epidemiological exposure assessment, exchanged information and ideas on the use of biomarkers of exposure in molecular epidemiology studies and summarized the current knowledge on methods and approaches for biomarker-based exposure assessment. This report presents the state of science regarding biomarker-based exposure assessment of the four most common neurocarcinogens: acrylamide, 1,3-butadiene, N-nitroso compounds, and polycyclic aromatic hydrocarbons. Importantly, these chemicals are also carcinogenic in other organs; therefore, this discussion is useful for environmental epidemiologists studying all cancer types.

Full Text

Duke Authors

Cited Authors

  • Il'yasova, D; McCarthy, BJ; Erdal, S; Shimek, J; Goldstein, J; Doerge, DR; Myers, SR; Vineis, P; Wishnok, JS; Swenberg, JA; Bigner, DD; Davis, FG

Published Date

  • March 2009

Published In

Volume / Issue

  • 12 / 3

Start / End Page

  • 175 - 187

PubMed ID

  • 19466671

Pubmed Central ID

  • PMC3633093

Electronic International Standard Serial Number (EISSN)

  • 1521-6950

Digital Object Identifier (DOI)

  • 10.1080/10937400902894152


  • eng

Conference Location

  • England