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Salmonella disrupts lymph node architecture by TLR4-mediated suppression of homeostatic chemokines.

Publication ,  Journal Article
St John, AL; Abraham, SN
Published in: Nat Med
November 2009

We report that infection of draining lymph nodes (DLNs) by Salmonella typhimurium results in the specific downregulation of the homeostatic chemokines CCL21 and CXCL13, which are essential for normal DLN organization and function. Our data reveal that the mechanism of this suppression is dependent on S. typhimurium LPS (sLPS). The decrease in CCL21 expression involves interaction between sLPS and CCL21-producing cells within DLNs, triggering a distinct Toll-like receptor 4 (TLR4)-mediated host signaling response. In this response, suppressor of cytokine signaling-3 (Socs3) is upregulated, which negatively regulates mothers against decapentaplegic homolog-3 (Smad3)-initiated production of CCL21. Disruption of lymph node architecture and cellular trafficking enhances S. typhimurium virulence and could represent a mechanism of immune suppression used by pathogens that primarily target lymphoid tissue.

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Published In

Nat Med

DOI

EISSN

1546-170X

Publication Date

November 2009

Volume

15

Issue

11

Start / End Page

1259 / 1265

Location

United States

Related Subject Headings

  • Toll-Like Receptor 4
  • T-Lymphocytes
  • Suppressor of Cytokine Signaling Proteins
  • Suppressor of Cytokine Signaling 3 Protein
  • Smad3 Protein
  • Signal Transduction
  • Salmonella typhimurium
  • Salmonella Infections, Animal
  • Mutation
  • Mice, Knockout
 

Citation

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MLA
NLM
St John, A. L., & Abraham, S. N. (2009). Salmonella disrupts lymph node architecture by TLR4-mediated suppression of homeostatic chemokines. Nat Med, 15(11), 1259–1265. https://doi.org/10.1038/nm.2036
St John, Ashley L., and Soman N. Abraham. “Salmonella disrupts lymph node architecture by TLR4-mediated suppression of homeostatic chemokines.Nat Med 15, no. 11 (November 2009): 1259–65. https://doi.org/10.1038/nm.2036.
St John, Ashley L., and Soman N. Abraham. “Salmonella disrupts lymph node architecture by TLR4-mediated suppression of homeostatic chemokines.Nat Med, vol. 15, no. 11, Nov. 2009, pp. 1259–65. Pubmed, doi:10.1038/nm.2036.

Published In

Nat Med

DOI

EISSN

1546-170X

Publication Date

November 2009

Volume

15

Issue

11

Start / End Page

1259 / 1265

Location

United States

Related Subject Headings

  • Toll-Like Receptor 4
  • T-Lymphocytes
  • Suppressor of Cytokine Signaling Proteins
  • Suppressor of Cytokine Signaling 3 Protein
  • Smad3 Protein
  • Signal Transduction
  • Salmonella typhimurium
  • Salmonella Infections, Animal
  • Mutation
  • Mice, Knockout