Cell biology and physiology of the uroepithelium.

Journal Article (Journal Article;Review)

The uroepithelium sits at the interface between the urinary space and underlying tissues, where it forms a high-resistance barrier to ion, solute, and water flux, as well as pathogens. However, the uroepithelium is not simply a passive barrier; it can modulate the composition of the urine, and it functions as an integral part of a sensory web in which it receives, amplifies, and transmits information about its external milieu to the underlying nervous and muscular systems. This review examines our understanding of uroepithelial regeneration and how specializations of the outermost umbrella cell layer, including tight junctions, surface uroplakins, and dynamic apical membrane exocytosis/endocytosis, contribute to barrier function and how they are co-opted by uropathogenic bacteria to infect the uroepithelium. Furthermore, we discuss the presence and possible functions of aquaporins, urea transporters, and multiple ion channels in the uroepithelium. Finally, we describe potential mechanisms by which the uroepithelium can transmit information about the urinary space to the other tissues in the bladder proper.

Full Text

Duke Authors

Cited Authors

  • Khandelwal, P; Abraham, SN; Apodaca, G

Published Date

  • December 2009

Published In

Volume / Issue

  • 297 / 6

Start / End Page

  • F1477 - F1501

PubMed ID

  • 19587142

Pubmed Central ID

  • PMC2801337

Electronic International Standard Serial Number (EISSN)

  • 1522-1466

Digital Object Identifier (DOI)

  • 10.1152/ajprenal.00327.2009


  • eng

Conference Location

  • United States