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Mast cell-derived particles deliver peripheral signals to remote lymph nodes.

Publication ,  Journal Article
Kunder, CA; St John, AL; Li, G; Leong, KW; Berwin, B; Staats, HF; Abraham, SN
Published in: J Exp Med
October 26, 2009

During infection, signals from the periphery are known to reach draining lymph nodes (DLNs), but how these molecules, such as inflammatory cytokines, traverse the significant distances involved without dilution or degradation remains unclear. We show that peripheral mast cells, upon activation, release stable submicrometer heparin-based particles containing tumor necrosis factor and other proteins. These complexes enter lymphatic vessels and rapidly traffic to the DLNs. This physiological drug delivery system facilitates communication between peripheral sites of inflammation and remote secondary lymphoid tissues.

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Published In

J Exp Med

DOI

EISSN

1540-9538

Publication Date

October 26, 2009

Volume

206

Issue

11

Start / End Page

2455 / 2467

Location

United States

Related Subject Headings

  • Tumor Necrosis Factor-alpha
  • Tetradecanoylphorbol Acetate
  • Solubility
  • Signal Transduction
  • Recombinant Proteins
  • Rats, Sprague-Dawley
  • Rats
  • Mice, Inbred C57BL
  • Mice
  • Mast Cells
 

Citation

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Kunder, C. A., St John, A. L., Li, G., Leong, K. W., Berwin, B., Staats, H. F., & Abraham, S. N. (2009). Mast cell-derived particles deliver peripheral signals to remote lymph nodes. J Exp Med, 206(11), 2455–2467. https://doi.org/10.1084/jem.20090805
Kunder, Christian A., Ashley L. St John, Guojie Li, Kam W. Leong, Brent Berwin, Herman F. Staats, and Soman N. Abraham. “Mast cell-derived particles deliver peripheral signals to remote lymph nodes.J Exp Med 206, no. 11 (October 26, 2009): 2455–67. https://doi.org/10.1084/jem.20090805.
Kunder CA, St John AL, Li G, Leong KW, Berwin B, Staats HF, et al. Mast cell-derived particles deliver peripheral signals to remote lymph nodes. J Exp Med. 2009 Oct 26;206(11):2455–67.
Kunder, Christian A., et al. “Mast cell-derived particles deliver peripheral signals to remote lymph nodes.J Exp Med, vol. 206, no. 11, Oct. 2009, pp. 2455–67. Pubmed, doi:10.1084/jem.20090805.
Kunder CA, St John AL, Li G, Leong KW, Berwin B, Staats HF, Abraham SN. Mast cell-derived particles deliver peripheral signals to remote lymph nodes. J Exp Med. 2009 Oct 26;206(11):2455–2467.

Published In

J Exp Med

DOI

EISSN

1540-9538

Publication Date

October 26, 2009

Volume

206

Issue

11

Start / End Page

2455 / 2467

Location

United States

Related Subject Headings

  • Tumor Necrosis Factor-alpha
  • Tetradecanoylphorbol Acetate
  • Solubility
  • Signal Transduction
  • Recombinant Proteins
  • Rats, Sprague-Dawley
  • Rats
  • Mice, Inbred C57BL
  • Mice
  • Mast Cells