Mast cell-derived particles deliver peripheral signals to remote lymph nodes.

Published

Journal Article

During infection, signals from the periphery are known to reach draining lymph nodes (DLNs), but how these molecules, such as inflammatory cytokines, traverse the significant distances involved without dilution or degradation remains unclear. We show that peripheral mast cells, upon activation, release stable submicrometer heparin-based particles containing tumor necrosis factor and other proteins. These complexes enter lymphatic vessels and rapidly traffic to the DLNs. This physiological drug delivery system facilitates communication between peripheral sites of inflammation and remote secondary lymphoid tissues.

Full Text

Duke Authors

Cited Authors

  • Kunder, CA; St John, AL; Li, G; Leong, KW; Berwin, B; Staats, HF; Abraham, SN

Published Date

  • October 26, 2009

Published In

Volume / Issue

  • 206 / 11

Start / End Page

  • 2455 - 2467

PubMed ID

  • 19808250

Pubmed Central ID

  • 19808250

Electronic International Standard Serial Number (EISSN)

  • 1540-9538

Digital Object Identifier (DOI)

  • 10.1084/jem.20090805

Language

  • eng

Conference Location

  • United States