Pulmonary alveolar proteinosis in workers at an indium processing facility.

Journal Article (Journal Article)

Two cases of pulmonary alveolar proteinosis, including one death, occurred in workers at a facility producing indium-tin oxide (ITO), a compound used in recent years to make flat panel displays. Both workers were exposed to airborne ITO dust and had indium in lung tissue specimens. One worker was tested for autoantibodies to granulocytemacrophage-colonystimulating factor (GM-CSF) and found to have an elevated level. These cases suggest that inhalational exposure to ITO causes pulmonary alveolar proteinosis, which may occur via an autoimmune mechanism.

Full Text

Duke Authors

Cited Authors

  • Cummings, KJ; Donat, WE; Ettensohn, DB; Roggli, VL; Ingram, P; Kreiss, K

Published Date

  • March 1, 2010

Published In

Volume / Issue

  • 181 / 5

Start / End Page

  • 458 - 464

PubMed ID

  • 20019344

Pubmed Central ID

  • PMC3159086

Electronic International Standard Serial Number (EISSN)

  • 1535-4970

Digital Object Identifier (DOI)

  • 10.1164/rccm.200907-1022CR


  • eng

Conference Location

  • United States