Absence of correlation between nuclear morphometry and survival in stage I non-small cell lung carcinoma.


Journal Article

To evaluate the utility of nuclear morphometry as a prognostic indicator in lung cancer, 5-year follow-up information was obtained in 46 cases of surgically resected Stage I non-small cell lung cancer (NSCLC). Nuclear area, perimeter, major diameter, minor diameter, and nuclear shape factor were determined from representative histologic sections of the tumors with a computer-assisted digitizing system. The morphometric parameters were compared between patients with favorable outcome (Group I: alive with no evidence of disease, n = 17) and those with poor outcome (Group II: dead of disease or with recurrence of disease, n = 29). No significant differences in any of the morphometric parameters were found between tumors in Groups I and II for individual tumor cell types or the combined cases. Failure to demonstrate a correlation between morphometric parameters and prognosis in Stage I NSCLC indicates that future efforts to determine objective prognostic factors should concentrate on other variables, such as specific genetic abnormalities.

Full Text

Duke Authors

Cited Authors

  • Cagle, PT; Langston, C; Fraire, AE; Roggli, VL; Greenberg, SD

Published Date

  • May 15, 1992

Published In

Volume / Issue

  • 69 / 10

Start / End Page

  • 2454 - 2457

PubMed ID

  • 1314690

Pubmed Central ID

  • 1314690

International Standard Serial Number (ISSN)

  • 0008-543X

Digital Object Identifier (DOI)

  • 10.1002/1097-0142(19920515)69:10<2454::aid-cncr2820691012>3.0.co;2-k


  • eng

Conference Location

  • United States