Morphometric quantitation of tumor necrosis in stage 1 non-small cell carcinoma of lung: prognostic implications.


Journal Article

We objectively examined the extent of tumor necrosis by computer-assisted morphometry in 28 patients with surgically resected Stage I non-small cell carcinoma of lung. Fourteen of the 28 patients were long-term survivors (mean survival after diagnosis 94 mo) and 14 were short-term survivors (up to 62 mo after diagnosis). The extent of tumor necrosis was determined by means of a computer assisted digitizing system. The two sample t test and the two-tailed Wilcoxon rank score tests were used for statistical analysis of comparison of the extent of tumor necrosis between the two groups of patients. This morphometric study showed that the extent of tumor necrosis was significantly associated to the probability of long-term survival, with long surviving patients having a lesser degree of tumor necrosis (t = 2.75, p < 0.02, 2 sample t test, two-tailed, df = 26). These findings reaffirm previous subjective data, derived from pathologist assessment of tumor necrosis, and suggest that morphometric evaluation of tumor necrosis may play a useful adjunct role in predicting prognosis of carcinoma of lung.

Full Text

Duke Authors

Cited Authors

  • Shahab, I; Fraire, AE; Greenberg, SD; Johnson, EH; Langston, C; Roggli, VL

Published Date

  • September 1992

Published In

Volume / Issue

  • 5 / 5

Start / End Page

  • 521 - 524

PubMed ID

  • 1344816

Pubmed Central ID

  • 1344816

International Standard Serial Number (ISSN)

  • 0893-3952


  • eng

Conference Location

  • United States