Prognostic factors and treatment effects on survival in erythroleukemia: a retrospective study of 134 cases.

Published

Journal Article

A total of 134 cases of erythroleukemia (119 from the literature and 15 of the authors' patients) were reviewed in an attempt to correlate survival with age, sex, hepatomegaly, splenomegaly, lymphadenopathy, infection, or hemorrhagic complications at initial presentation; hemoglobin (Hgb), white blood cell (WBC) count, and platelet count; percent myeloblasts in the marrow at diagnosis; and treatment regimens employed. Statistical methods included single classification analysis of variance, nonparametric analysis of variance (Kruskal-Wallis method), contingency table analysis, and correlation coefficient determination for numerical data. No significant correlation between survival and age, sex, hepatomegaly, lymphadenopathy, infection, or hemorrhagic phenomena was found. Improved survival was noted in patients without splenomegaly, and in daunorubicin-treated cases in contrast to those treated with other chemotherapeutic agents. A positive correlation between survival and initial Hgb and WBC was also noted. Erythroleukemia complicating a chronic myeloproliferative disorder had a worse prognosis than de novo erythroleukemia.

Full Text

Duke Authors

Cited Authors

  • Roggli, VL; Subach, J; Saleem, A

Published Date

  • September 1, 1981

Published In

Volume / Issue

  • 48 / 5

Start / End Page

  • 1101 - 1105

PubMed ID

  • 6944145

Pubmed Central ID

  • 6944145

International Standard Serial Number (ISSN)

  • 0008-543X

Language

  • eng

Conference Location

  • United States