Silica-induced pleural disease: an unusual case mimicking malignant mesothelioma.

Journal Article (Journal Article;Review)

A 57-year-old man with a history of exposure to silica for 32 years presented with pleural thickening of the lower lobe of the left lung and a chronic right-sided pleural effusion without any radiographic evidence of parenchymal nodules in either lung. Light microscopic examination of a left visceral pleural biopsy specimen revealed markedly thickened pleura with fibrosis and macrophages containing birefringent silica and silicates. Occasional rounded intrapleural silicotic nodules were present. The underlying lung tissue did not show fibrosis or silicotic nodules. An energy-dispersive x-ray analysis confirmed the presence of silica. In the absence of lung involvement, this case represents a very unusual pathologic reaction caused by silica and silicates and adds to the clinical differential diagnosis of chronic pleuritis and malignant mesothelioma.

Full Text

Duke Authors

Cited Authors

  • Zeren, EH; Colby, TV; Roggli, VL

Published Date

  • November 5, 1997

Published In

Volume / Issue

  • 112 / 5

Start / End Page

  • 1436 - 1438

PubMed ID

  • 9367490

International Standard Serial Number (ISSN)

  • 0012-3692

Digital Object Identifier (DOI)

  • 10.1378/chest.112.5.1436


  • eng

Conference Location

  • United States