Asbestos body concentrations in human lung: predictions from asbestos body counts in tissue sections with a mathematical model.

Journal Article (Journal Article)

A mathematical model for predicting the concentration (Nv) of asbestos bodies (AB) in human tissue from the count (No) of these bodies in planar tissue sections is presented. The result is the equation Nv = No/[0.54 X A X (La + t)], giving the concentration of AB in numbers per gram of wet lung tissue. La, the average length (in microns) of the AB, is specific for each case; A is the area (square millimeters) of the tissue counted, and t is the thickness of the section (in microns). This equation fits experimental digestion results to a multiplicative error factor of less than 3. When an estimate of La, such as 51.6 microns, is used, the equation is less accurate but probably sufficiently accurate for the screening of lung specimens.

Full Text

Duke Authors

Cited Authors

  • Vollmer, RT; Roggli, VL

Published Date

  • July 1985

Published In

Volume / Issue

  • 16 / 7

Start / End Page

  • 713 - 718

PubMed ID

  • 4007847

International Standard Serial Number (ISSN)

  • 0046-8177

Digital Object Identifier (DOI)

  • 10.1016/s0046-8177(85)80157-x


  • eng

Conference Location

  • United States