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The diagnosis of desmoplastic malignant mesothelioma and its distinction from fibrous pleurisy: a histologic and immunohistochemical analysis of 31 cases including p53 immunostaining.

Publication ,  Journal Article
Mangano, WE; Cagle, PT; Churg, A; Vollmer, RT; Roggli, VL
Published in: Am J Clin Pathol
August 1998

We studied 31 patients with fibrotic pleural lesions and classified them as desmoplastic malignant mesothelioma (DMM) or fibrous pleurisy (FP) using predetermined histologic criteria, including a paucicellular fibrotic pleural lesion with a storiform pattern or the "patternless pattern " of Stout, plus 1 or more of the following: invasion of chest wall or lung, bland necrosis, frankly sarcomatoid areas, and distant metastases. Staining for p53 was performed in 22 cases. Follow-up was obtained on all cases and compared with the histologic diagnoses. For 24 cases, the consensus diagnosis was DMM; 19 of these displayed frankly sarcomatoid areas, 16 showed invasion, and 8, bland necrosis. Of the 24, 23 patients died of disease and 1 was alive with disease. The remaining 7 cases were classified as FP, and all were alive without disease. The concordance among 3 pathologists using the criteria was excellent. Staining for p53 was more common in DMM than in FP, but the difference was not statistically significant. The concordance in interpreting the p53 stains by the same 3 pathologists was moderate. The distinction between DMM and FP in a predominantly fibrotic pleural lesion can be made in most cases with adequate sampling and the use of specific criteria.

Duke Scholars

Published In

Am J Clin Pathol

DOI

ISSN

0002-9173

Publication Date

August 1998

Volume

110

Issue

2

Start / End Page

191 / 199

Location

England

Related Subject Headings

  • Tumor Suppressor Protein p53
  • Staining and Labeling
  • Sarcoma
  • Pleurisy
  • Pleural Neoplasms
  • Pathology
  • Neoplasm Invasiveness
  • Necrosis
  • Middle Aged
  • Mesothelioma
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Mangano, W. E., Cagle, P. T., Churg, A., Vollmer, R. T., & Roggli, V. L. (1998). The diagnosis of desmoplastic malignant mesothelioma and its distinction from fibrous pleurisy: a histologic and immunohistochemical analysis of 31 cases including p53 immunostaining. Am J Clin Pathol, 110(2), 191–199. https://doi.org/10.1093/ajcp/110.2.191
Mangano, W. E., P. T. Cagle, A. Churg, R. T. Vollmer, and V. L. Roggli. “The diagnosis of desmoplastic malignant mesothelioma and its distinction from fibrous pleurisy: a histologic and immunohistochemical analysis of 31 cases including p53 immunostaining.Am J Clin Pathol 110, no. 2 (August 1998): 191–99. https://doi.org/10.1093/ajcp/110.2.191.
Mangano, W. E., et al. “The diagnosis of desmoplastic malignant mesothelioma and its distinction from fibrous pleurisy: a histologic and immunohistochemical analysis of 31 cases including p53 immunostaining.Am J Clin Pathol, vol. 110, no. 2, Aug. 1998, pp. 191–99. Pubmed, doi:10.1093/ajcp/110.2.191.
Journal cover image

Published In

Am J Clin Pathol

DOI

ISSN

0002-9173

Publication Date

August 1998

Volume

110

Issue

2

Start / End Page

191 / 199

Location

England

Related Subject Headings

  • Tumor Suppressor Protein p53
  • Staining and Labeling
  • Sarcoma
  • Pleurisy
  • Pleural Neoplasms
  • Pathology
  • Neoplasm Invasiveness
  • Necrosis
  • Middle Aged
  • Mesothelioma