Composition of lung lavage in pulmonary alveolar microlithiasis.

Journal Article (Journal Article)

A case of pulmonary alveolar microlithiasis (PAM) is reported wherein total lung lavage was performed for relief of dyspnea. Characterization of the lavage material and examination of the microliths isolated from the lavage fluid confirmed previous reports of their spherical-ovoid shape and a 2:1 calcium to phosphate composition. The microliths contained considerable amounts of ionizable iron and generated oxidants in an in vitro system. A detailed biochemical analysis of the lavage fluid reflected elevations in total protein, phosphatidylserine, phosphatidylglycerol and the ratio of phosphatidylglycerol to phosphatidylinositol. Surfactant apoprotein-A levels approximated that of normal patients. The potential roles of oxidant generation and alterations in surfactant metabolism are discussed in the context of the pathogenesis of PAM.

Full Text

Duke Authors

Cited Authors

  • Pracyk, JB; Simonson, SG; Young, SL; Ghio, AJ; Roggli, VL; Piantadosi, CA

Published Date

  • 1996

Published In

Volume / Issue

  • 63 / 4

Start / End Page

  • 254 - 260

PubMed ID

  • 8815975

International Standard Serial Number (ISSN)

  • 0025-7931

Digital Object Identifier (DOI)

  • 10.1159/000196556


  • eng

Conference Location

  • Switzerland