Pulmonary blastoma: an ultrastructural and histochemical study.

Published

Journal Article

We present a unique case of pulmonary blastoma and describe its histology and ultrastructure. The stromal component exhibited bizarre multinucleated giant cells containing previously undescribed granules. These membrane-limited granules were eosinophilic, periodic acid-Schiff positive, diastase resistant, acid phosphatase and nonspecific esterase negative, immunohistologically negative for lysozyme, albumin, and gamma globulin, and often homogeneously electron dense. A similar electron-dense material accumulated in the rough endoplasmic reticulum of these stromal giant cells, suggesting that the material in the granules is synthetic. The material appeared to be a glycoprotein but was not alpha1-antitrypsin, alpha-fetoprotein, or human chorionic gonadotropin by immunohistologic techniques. These stromal cell granules differ from granules described in epithelial cells of other pulmonary blastomas but resemble granules found in some sarcomas.

Full Text

Duke Authors

Cited Authors

  • Jackson, MD; Albrecht, R; Roggli, VL; Shelburne, JD

Published Date

  • 1984

Published In

Volume / Issue

  • 7 / 4

Start / End Page

  • 259 - 268

PubMed ID

  • 6537093

Pubmed Central ID

  • 6537093

International Standard Serial Number (ISSN)

  • 0191-3123

Digital Object Identifier (DOI)

  • 10.3109/01913128409141486

Language

  • eng

Conference Location

  • England