Skip to main content

National survey on the susceptibility of Bacteroides fragilis group: report and analysis of trends in the United States from 1997 to 2004.

Publication ,  Journal Article
Snydman, DR; Jacobus, NV; McDermott, LA; Ruthazer, R; Golan, Y; Goldstein, EJC; Finegold, SM; Harrell, LJ; Hecht, DW; Jenkins, SG; Pierson, C ...
Published in: Antimicrob Agents Chemother
May 2007

The susceptibility trends for the species of the Bacteroides fragilis group against various antibiotics from 1997 to 2004 were determined by using data for 5,225 isolates referred by 10 medical centers. The antibiotic test panel included ertapenem, imipenem, meropenem, ampicillin-sulbactam, piperacillin-tazobactam, cefoxitin, clindamycin, moxifloxacin, tigecycline, chloramphenicol, and metronidazole. From 1997 to 2004 there were decreases in the geometric mean (GM) MICs of imipenem, meropenem, piperacillin-tazobactam, and cefoxitin for many of the species within the group. B. distasonis showed the highest rates of resistance to most of the beta-lactams. B. fragilis, B. ovatus, and B. thetaiotaomicron showed significantly higher GM MICs and rates of resistance to clindamycin over time. The rate of resistance to moxifloxacin of B. vulgatus was very high (MIC range for the 8-year study period, 38% to 66%). B. fragilis, B. ovatus, and B. distasonis and other Bacteroides spp. exhibited significant increases in the rates of resistance to moxifloxacin over the 8 years. Resistance rates and GM MICs for tigecycline were low and stable during the 5-year period over which this agent was studied. All isolates were susceptible to chloramphenicol (MICs < 16 microg/ml). In 2002, one isolate resistant to metronidazole (MIC = 64 microg/ml) was noted. These data indicate changes in susceptibility over time; surprisingly, some antimicrobial agents are more active now than they were 5 years ago.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Antimicrob Agents Chemother

DOI

ISSN

0066-4804

Publication Date

May 2007

Volume

51

Issue

5

Start / End Page

1649 / 1655

Location

United States

Related Subject Headings

  • United States
  • Time Factors
  • Microbiology
  • Microbial Sensitivity Tests
  • Drug Resistance, Bacterial
  • Bacteroides fragilis
  • Bacteroides
  • Anti-Bacterial Agents
  • 3214 Pharmacology and pharmaceutical sciences
  • 3207 Medical microbiology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Snydman, D. R., Jacobus, N. V., McDermott, L. A., Ruthazer, R., Golan, Y., Goldstein, E. J. C., … Gorbach, S. L. (2007). National survey on the susceptibility of Bacteroides fragilis group: report and analysis of trends in the United States from 1997 to 2004. Antimicrob Agents Chemother, 51(5), 1649–1655. https://doi.org/10.1128/AAC.01435-06
Snydman, D. R., N. V. Jacobus, L. A. McDermott, R. Ruthazer, Y. Golan, E. J. C. Goldstein, S. M. Finegold, et al. “National survey on the susceptibility of Bacteroides fragilis group: report and analysis of trends in the United States from 1997 to 2004.Antimicrob Agents Chemother 51, no. 5 (May 2007): 1649–55. https://doi.org/10.1128/AAC.01435-06.
Snydman DR, Jacobus NV, McDermott LA, Ruthazer R, Golan Y, Goldstein EJC, et al. National survey on the susceptibility of Bacteroides fragilis group: report and analysis of trends in the United States from 1997 to 2004. Antimicrob Agents Chemother. 2007 May;51(5):1649–55.
Snydman, D. R., et al. “National survey on the susceptibility of Bacteroides fragilis group: report and analysis of trends in the United States from 1997 to 2004.Antimicrob Agents Chemother, vol. 51, no. 5, May 2007, pp. 1649–55. Pubmed, doi:10.1128/AAC.01435-06.
Snydman DR, Jacobus NV, McDermott LA, Ruthazer R, Golan Y, Goldstein EJC, Finegold SM, Harrell LJ, Hecht DW, Jenkins SG, Pierson C, Venezia R, Yu V, Rihs J, Gorbach SL. National survey on the susceptibility of Bacteroides fragilis group: report and analysis of trends in the United States from 1997 to 2004. Antimicrob Agents Chemother. 2007 May;51(5):1649–1655.

Published In

Antimicrob Agents Chemother

DOI

ISSN

0066-4804

Publication Date

May 2007

Volume

51

Issue

5

Start / End Page

1649 / 1655

Location

United States

Related Subject Headings

  • United States
  • Time Factors
  • Microbiology
  • Microbial Sensitivity Tests
  • Drug Resistance, Bacterial
  • Bacteroides fragilis
  • Bacteroides
  • Anti-Bacterial Agents
  • 3214 Pharmacology and pharmaceutical sciences
  • 3207 Medical microbiology