Evidence that SOX2 overexpression is oncogenic in the lung.

Published online

Journal Article

BACKGROUND: SOX2 (Sry-box 2) is required to maintain a variety of stem cells, is overexpressed in some solid tumors, and is expressed in epithelial cells of the lung. METHODOLOGY/PRINCIPAL FINDINGS: We show that SOX2 is overexpressed in human squamous cell lung tumors and some adenocarcinomas. We have generated mouse models in which Sox2 is upregulated in epithelial cells of the lung during development and in the adult. In both cases, overexpression leads to extensive hyperplasia. In the terminal bronchioles, a trachea-like pseudostratified epithelium develops with p63-positive cells underlying columnar cells. Over 12-34 weeks, about half of the mice expressing the highest levels of Sox2 develop carcinoma. These tumors resemble adenocarcinoma but express the squamous marker, Trp63 (p63). CONCLUSIONS: These findings demonstrate that Sox2 overexpression both induces a proximal phenotype in the distal airways/alveoli and leads to cancer.

Full Text

Duke Authors

Cited Authors

  • Lu, Y; Futtner, C; Rock, JR; Xu, X; Whitworth, W; Hogan, BLM; Onaitis, MW

Published Date

  • June 10, 2010

Published In

Volume / Issue

  • 5 / 6

Start / End Page

  • e11022 -

PubMed ID

  • 20548776

Pubmed Central ID

  • 20548776

Electronic International Standard Serial Number (EISSN)

  • 1932-6203

Digital Object Identifier (DOI)

  • 10.1371/journal.pone.0011022

Language

  • eng

Conference Location

  • United States