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Drug-induced granulomatous interstitial nephritis in a pediatric patient.

Publication ,  Journal Article
Tong, JE; Howell, DN; Foreman, JW
Published in: Pediatr Nephrol
February 2007

Acute interstitial nephritis (AIN) is a known cause of acute renal failure in children. In most instances, drug therapy is the offending agent. Although granuloma formation has been observed in drug-induced interstitial nephritis, it is not a commonly associated manifestation. This is a case of a 15-year-old white female with Tetralogy of Fallot and pulmonary atresia who developed acute renal failure secondary to drug-induced interstitial nephritis and renal granulomas. In addition to interstitial edema with eosinophils and lymphocytes, her renal biopsy showed interstitial granulomas, immune complexes within tubular basement membranes, and the unusual feature of multinucleated giant cells engulfing tubules. Her acute renal failure resolved after the withdrawal of antibiotics and the initiation of intravenous steroid therapy.

Duke Scholars

Published In

Pediatr Nephrol

DOI

ISSN

0931-041X

Publication Date

February 2007

Volume

22

Issue

2

Start / End Page

306 / 309

Location

Germany

Related Subject Headings

  • Urology & Nephrology
  • Prednisone
  • Nephritis, Interstitial
  • Kidney
  • Humans
  • Granuloma
  • Glucocorticoids
  • Female
  • Cefuroxime
  • Biopsy
 

Citation

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MLA
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Tong, J. E., Howell, D. N., & Foreman, J. W. (2007). Drug-induced granulomatous interstitial nephritis in a pediatric patient. Pediatr Nephrol, 22(2), 306–309. https://doi.org/10.1007/s00467-006-0318-9
Tong, James E., David N. Howell, and John W. Foreman. “Drug-induced granulomatous interstitial nephritis in a pediatric patient.Pediatr Nephrol 22, no. 2 (February 2007): 306–9. https://doi.org/10.1007/s00467-006-0318-9.
Tong JE, Howell DN, Foreman JW. Drug-induced granulomatous interstitial nephritis in a pediatric patient. Pediatr Nephrol. 2007 Feb;22(2):306–9.
Tong, James E., et al. “Drug-induced granulomatous interstitial nephritis in a pediatric patient.Pediatr Nephrol, vol. 22, no. 2, Feb. 2007, pp. 306–09. Pubmed, doi:10.1007/s00467-006-0318-9.
Tong JE, Howell DN, Foreman JW. Drug-induced granulomatous interstitial nephritis in a pediatric patient. Pediatr Nephrol. 2007 Feb;22(2):306–309.
Journal cover image

Published In

Pediatr Nephrol

DOI

ISSN

0931-041X

Publication Date

February 2007

Volume

22

Issue

2

Start / End Page

306 / 309

Location

Germany

Related Subject Headings

  • Urology & Nephrology
  • Prednisone
  • Nephritis, Interstitial
  • Kidney
  • Humans
  • Granuloma
  • Glucocorticoids
  • Female
  • Cefuroxime
  • Biopsy