The uncertain significance of anti-glomerular basement membrane antibody among HIV-infected persons with kidney disease.

Journal Article

Glomerular lesions that complicate patients with human immunodeficiency virus (HIV) infection include HIV-associated nephropathy, membranous glomerulopathy, and immune-complex glomerulonephritides. This case series presents 3 patients with clinically significant renal disease and positive test results for anti-glomerular basement membrane (anti-GBM) antigen. Characteristic histological findings that would suggest anti-GBM antibodies have a significant role in the pathological state of each patient's kidney disease were absent. In addition, each patient recovered without specific treatment for anti-GBM disease. This case series suggests that anti-GBM antibodies likely are related to the B-cell expansion previously described in patients with HIV infection. We propose that clinicians interpret results of anti-GBM antibody tests carefully for patients with HIV infection, considering biopsy before empiric therapy, particularly in a clinical presentation that is atypical for Goodpasture disease.

Full Text

Duke Authors

Cited Authors

  • Szczech, LA; Anderson, A; Ramers, C; Engeman, J; Ellis, M; Butterly, D; Howell, DN

Published Date

  • October 2006

Published In

Volume / Issue

  • 48 / 4

Start / End Page

  • e55 - e59

PubMed ID

  • 16997046

Electronic International Standard Serial Number (EISSN)

  • 1523-6838

Digital Object Identifier (DOI)

  • 10.1053/j.ajkd.2006.06.007

Language

  • eng

Conference Location

  • United States