The uncertain significance of anti-glomerular basement membrane antibody among HIV-infected persons with kidney disease.
Journal Article (Journal Article)
Glomerular lesions that complicate patients with human immunodeficiency virus (HIV) infection include HIV-associated nephropathy, membranous glomerulopathy, and immune-complex glomerulonephritides. This case series presents 3 patients with clinically significant renal disease and positive test results for anti-glomerular basement membrane (anti-GBM) antigen. Characteristic histological findings that would suggest anti-GBM antibodies have a significant role in the pathological state of each patient's kidney disease were absent. In addition, each patient recovered without specific treatment for anti-GBM disease. This case series suggests that anti-GBM antibodies likely are related to the B-cell expansion previously described in patients with HIV infection. We propose that clinicians interpret results of anti-GBM antibody tests carefully for patients with HIV infection, considering biopsy before empiric therapy, particularly in a clinical presentation that is atypical for Goodpasture disease.
Full Text
Duke Authors
Cited Authors
- Szczech, LA; Anderson, A; Ramers, C; Engeman, J; Ellis, M; Butterly, D; Howell, DN
Published Date
- October 2006
Published In
Volume / Issue
- 48 / 4
Start / End Page
- e55 - e59
PubMed ID
- 16997046
Electronic International Standard Serial Number (EISSN)
- 1523-6838
Digital Object Identifier (DOI)
- 10.1053/j.ajkd.2006.06.007
Language
- eng
Conference Location
- United States