A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis.

Journal Article

Focal and segmental glomerulosclerosis (FSGS) is a kidney disorder of unknown etiology, and up to 20% of patients on dialysis have been diagnosed with it. Here we show that a large family with hereditary FSGS carries a missense mutation in the TRPC6 gene on chromosome 11q, encoding the ion-channel protein transient receptor potential cation channel 6 (TRPC6). The proline-to-glutamine substitution at position 112, which occurs in a highly conserved region of the protein, enhances TRPC6-mediated calcium signals in response to agonists such as angiotensin II and appears to alter the intracellular distribution of TRPC6 protein. Previous work has emphasized the importance of cytoskeletal and structural proteins in proteinuric kidney diseases. Our findings suggest an alternative mechanism for the pathogenesis of glomerular disease.

Full Text

Duke Authors

Cited Authors

  • Winn, MP; Conlon, PJ; Lynn, KL; Farrington, MK; Creazzo, T; Hawkins, AF; Daskalakis, N; Kwan, SY; Ebersviller, S; Burchette, JL; Pericak-Vance, MA; Howell, DN; Vance, JM; Rosenberg, PB

Published Date

  • June 17, 2005

Published In

Volume / Issue

  • 308 / 5729

Start / End Page

  • 1801 - 1804

PubMed ID

  • 15879175

Electronic International Standard Serial Number (EISSN)

  • 1095-9203

Digital Object Identifier (DOI)

  • 10.1126/science.1106215

Language

  • eng

Conference Location

  • United States