Distribution of tin in brain subcellular fractions following the administration of trimethyl tin and triethyl tin to the rat.

Published

Journal Article

The time course of tin distribution in homogenates and subcellular fractions of rat brain was determined following the acute administration of trimethyl tin (TMT) and triethyl tin (TET) to the rat. Exposure to TMT resulted in lower concentrations but greater persistence of tin in subcellular fractions compared to exposure to TET. A delayed accumulation of tin in the mitochondrial fraction was observed following the administration of TMT but not TET. Analysis of total protein and mitochondrial markers did not reveal differences between the compositions of mitochondrial fractions prepared from control and TMT-treated subjects.

Full Text

Duke Authors

Cited Authors

  • Cook, LL; Heath, SM; O'Callaghan, JP

Published Date

  • 1984-05-01

Published In

Volume / Issue

  • 73 / 3

Start / End Page

  • 564 - 568

PubMed ID

  • 6719471

Pubmed Central ID

  • 6719471

Electronic International Standard Serial Number (EISSN)

  • 1096-0333

International Standard Serial Number (ISSN)

  • 0041-008X

Digital Object Identifier (DOI)

  • 10.1016/0041-008x(84)90109-1

Language

  • eng