Gaussian process methods for estimating cortical maps.

Journal Article (Journal Article)

A striking feature of cortical organization is that the encoding of many stimulus features, for example orientation or direction selectivity, is arranged into topographic maps. Functional imaging methods such as optical imaging of intrinsic signals, voltage sensitive dye imaging or functional magnetic resonance imaging are important tools for studying the structure of cortical maps. As functional imaging measurements are usually noisy, statistical processing of the data is necessary to extract maps from the imaging data. We here present a probabilistic model of functional imaging data based on Gaussian processes. In comparison to conventional approaches, our model yields superior estimates of cortical maps from smaller amounts of data. In addition, we obtain quantitative uncertainty estimates, i.e. error bars on properties of the estimated map. We use our probabilistic model to study the coding properties of the map and the role of noise-correlations by decoding the stimulus from single trials of an imaging experiment.

Full Text

Duke Authors

Cited Authors

  • Macke, JH; Gerwinn, S; White, LE; Kaschube, M; Bethge, M

Published Date

  • May 15, 2011

Published In

Volume / Issue

  • 56 / 2

Start / End Page

  • 570 - 581

PubMed ID

  • 20472075

Electronic International Standard Serial Number (EISSN)

  • 1095-9572

Digital Object Identifier (DOI)

  • 10.1016/j.neuroimage.2010.04.272


  • eng

Conference Location

  • United States