Skip to main content
Journal cover image

The effects of acute afterload change on systolic ventricular function in conscious dogs with normal vs. failing hearts.

Publication ,  Journal Article
Thompson, RB; van den Bos, EJ; Esposito, DJ; Owen, CH; Glower, DD
Published in: Eur J Heart Fail
December 2003

BACKGROUND: To date, no data exist on the linearity and, therefore, the usefulness of the preload recruitable stroke work (PRSW) and end-systolic pressure-volume (ESPVR) relationships during acute afterload changes in heart failure. AIMS: Our aim was, therefore, to characterize both relationships in a model of ventricular pacing induced heart failure at baseline and during acute changes in afterload. METHODS: Dynamic left ventricular volume and transmural pressure were measured in 10 conscious dogs using sonomicrometry and micromanometry under control conditions and during heart failure produced by 3 weeks of rapid right ventricular pacing. Afterload was varied from baseline with intravenous infusions of nitroprusside and phenylephrine. Left ventricular function was assessed using the PRSW and ESPVR relationships. RESULTS: Cardiac output demonstrated a linear inverse relationship with afterload in both normal and failing hearts (r2>0.5, P<0.001) with failure producing a parallel, downward shift of the afterload (x) vs. cardiac output (y) relationship (P<0.01). Yet, afterload variation did not affect PRSW or ESPVR relationships in either normal or failing hearts (r2<0.12, P>0.05). CONCLUSION: Thus, the PRSW and ESPVR relationships are insensitive to acute afterload changes in both failing and normal hearts, and the failing left ventricle is no more afterload-sensitive than the normal heart.

Duke Scholars

Published In

Eur J Heart Fail

DOI

ISSN

1388-9842

Publication Date

December 2003

Volume

5

Issue

6

Start / End Page

741 / 749

Location

England

Related Subject Headings

  • Ventricular Function, Left
  • Vasodilator Agents
  • Vasoconstrictor Agents
  • Stroke Volume
  • Phenylephrine
  • Nitroprusside
  • Linear Models
  • Heart Failure
  • Echocardiography
  • Dogs
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Thompson, R. B., van den Bos, E. J., Esposito, D. J., Owen, C. H., & Glower, D. D. (2003). The effects of acute afterload change on systolic ventricular function in conscious dogs with normal vs. failing hearts. Eur J Heart Fail, 5(6), 741–749. https://doi.org/10.1016/s1388-9842(03)00152-1
Thompson, Richard B., Ewout J. van den Bos, David J. Esposito, Clarence H. Owen, and Donald D. Glower. “The effects of acute afterload change on systolic ventricular function in conscious dogs with normal vs. failing hearts.Eur J Heart Fail 5, no. 6 (December 2003): 741–49. https://doi.org/10.1016/s1388-9842(03)00152-1.
Thompson RB, van den Bos EJ, Esposito DJ, Owen CH, Glower DD. The effects of acute afterload change on systolic ventricular function in conscious dogs with normal vs. failing hearts. Eur J Heart Fail. 2003 Dec;5(6):741–9.
Thompson, Richard B., et al. “The effects of acute afterload change on systolic ventricular function in conscious dogs with normal vs. failing hearts.Eur J Heart Fail, vol. 5, no. 6, Dec. 2003, pp. 741–49. Pubmed, doi:10.1016/s1388-9842(03)00152-1.
Thompson RB, van den Bos EJ, Esposito DJ, Owen CH, Glower DD. The effects of acute afterload change on systolic ventricular function in conscious dogs with normal vs. failing hearts. Eur J Heart Fail. 2003 Dec;5(6):741–749.
Journal cover image

Published In

Eur J Heart Fail

DOI

ISSN

1388-9842

Publication Date

December 2003

Volume

5

Issue

6

Start / End Page

741 / 749

Location

England

Related Subject Headings

  • Ventricular Function, Left
  • Vasodilator Agents
  • Vasoconstrictor Agents
  • Stroke Volume
  • Phenylephrine
  • Nitroprusside
  • Linear Models
  • Heart Failure
  • Echocardiography
  • Dogs