Severe erythroderma as a complication of continuous epoprostenol therapy.
Epoprostenol is a vasodilator that is produced by vascular endothelial cells and is currently the "gold standard" therapy for patients with severe primary pulmonary hypertension or pulmonary hypertension secondary to collagen vascular disease. Hypersensitivity to the drug has not been reported. We report a case of a patient with pulmonary hypertension and undifferentiated connective tissue disease who, after 2 months of treatment with epoprostenol, presented with rapidly progressive erythema, scaling, nausea and vomiting, and fever. Test results from a skin biopsy specimen were consistent with a drug reaction. The patient' condition improved after rapid tapering of her epoprostenol and administration of corticosteroids. Epoprostenol may be associated rarely with severe erythroderma.
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Related Subject Headings
- Respiratory System
- Middle Aged
- Hypertension, Pulmonary
- Humans
- Female
- Epoprostenol
- Drug Hypersensitivity
- Dermatitis, Exfoliative
- Antihypertensive Agents
- 3202 Clinical sciences
Citation
Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Respiratory System
- Middle Aged
- Hypertension, Pulmonary
- Humans
- Female
- Epoprostenol
- Drug Hypersensitivity
- Dermatitis, Exfoliative
- Antihypertensive Agents
- 3202 Clinical sciences