Ferulic acid stabilizes a solution of vitamins C and E and doubles its photoprotection of skin.

Journal Article (Journal Article)

Ferulic acid is a potent ubiquitous plant antioxidant. Its incorporation into a topical solution of 15%l-ascorbic acid and 1%alpha-tocopherol improved chemical stability of the vitamins (C+E) and doubled photoprotection to solar-simulated irradiation of skin from 4-fold to approximately 8-fold as measured by both erythema and sunburn cell formation. Inhibition of apoptosis was associated with reduced induction of caspase-3 and caspase-7. This antioxidant formulation efficiently reduced thymine dimer formation. This combination of pure natural low molecular weight antioxidants provides meaningful synergistic protection against oxidative stress in skin and should be useful for protection against photoaging and skin cancer.

Full Text

Duke Authors

Cited Authors

  • Lin, F-H; Lin, J-Y; Gupta, RD; Tournas, JA; Burch, JA; Selim, MA; Monteiro-Riviere, NA; Grichnik, JM; Zielinski, J; Pinnell, SR

Published Date

  • October 2005

Published In

Volume / Issue

  • 125 / 4

Start / End Page

  • 826 - 832

PubMed ID

  • 16185284

International Standard Serial Number (ISSN)

  • 0022-202X

Digital Object Identifier (DOI)

  • 10.1111/j.0022-202X.2005.23768.x


  • eng

Conference Location

  • United States