Basal cell-signet-ring squamous cell carcinoma of the eyelid.


Journal Article

A 93-year-old woman developed a mass on her right lower eyelid that was present for more than 6 months but underwent rapid expansion during several weeks prior to her ophthalmological evaluation. Examination revealed an approximately 1.8 cm in diameter, fleshy, fungating growth involving more than 60% of the right lower eyelid. Excisional biopsy disclosed a neoplasm arising from the epidermis composed of adjoining basal cell and signet-ring squamous cell carcinoma, without a transition zone. The cells comprising the basal and squamous cell carcinomas were distinct immunophenotypically, with only the basal cell carcinoma reacting with Ber-EP4 and CAM 5.2 antibodies. To our knowledge, this case represents the first example of a collision tumor composed of basal cell and signet-ring squamous cell carcinoma.

Full Text

Duke Authors

Cited Authors

  • Proia, AD; Selim, MA; Reutter, JC; Michon, JJ

Published Date

  • March 2006

Published In

Volume / Issue

  • 130 / 3

Start / End Page

  • 393 - 396

PubMed ID

  • 16519572

Pubmed Central ID

  • 16519572

Electronic International Standard Serial Number (EISSN)

  • 1543-2165

Digital Object Identifier (DOI)

  • 10.1043/1543-2165(2006)130[393:BCSCCO]2.0.CO;2


  • eng

Conference Location

  • United States