Evidence for infection, inflammation and shock in sudden infant death: parallels between a neonatal rat model of sudden death and infants who died of sudden infant death syndrome.

Journal Article (Journal Article)

This study compared pathological findings from a neonatal rat model of sudden death with those from 40 sudden infant death syndrome (SIDS) infants collected at autopsy. In the rat model, influenza A virus was administered intranasally on postnatal day 10, and on day 12 a sublethal, intraperitoneal dose of Escherichia coli endotoxin; mortality was 80%. Tissue samples from the animals and infants were fixed in formaldehyde, embedded in paraffin, and sections stained with hematoxylin and eosin. Tissues from the SIDS specimens were additionally cultured for bacteria and viruses; post-mortem blood samples were evaluated for signs of inflammation. All sections were examined by a pediatric forensic pathologist familiar with SIDS pathology. Comparisons between the rat model and the human SIDS cases revealed that both exhibited gross and microscopic pathology related to organ shock, possibly associated with the presence of endotoxin. Uncompensated shock appeared to be a likely factor that caused death in both infants and rat pups. Response to a shock-inducing event might have played an important role in the events leading to death. The similarities between the neonatal rats and the human cases indicate that further research with the model might elucidate additional aspects of SIDS pathology.

Full Text

Duke Authors

Cited Authors

  • Blood-Siegfried, J; Rambaud, C; Nyska, A; Germolec, DR

Published Date

  • June 2008

Published In

Volume / Issue

  • 14 / 3

Start / End Page

  • 145 - 152

PubMed ID

  • 18562573

Pubmed Central ID

  • PMC2679510

Electronic International Standard Serial Number (EISSN)

  • 1753-4267

International Standard Serial Number (ISSN)

  • 1753-4259

Digital Object Identifier (DOI)

  • 10.1177/1753425908090730


  • eng