Alteration in regulation of inflammatory response to influenza a virus and endotoxin in suckling rat pups: a potential relationship to sudden infant death syndrome.

Journal Article (Journal Article)

Data increasingly implicate a possible role of immune and inflammatory responses to infection in sudden infant death syndrome (SIDS). We have previously described a dual challenge model that results in pathology, organ damage, vascular collapse and unexplained death similar to that seen in SIDS. In this study, we examined changes in inflammatory cytokine mRNA in the lung and liver and regulation of pathways associated with nitric oxide production. Our data suggest that priming of the immune system by mild viral infection disturbs normal inflammatory response to endotoxin. This results in an increased nitric oxide synthase production, most likely the cause of liver pathology and clotting abnormalities.

Full Text

Duke Authors

Cited Authors

  • Blood-Siegfried, J; Nyska, A; Geisenhoffer, K; Lieder, H; Moomaw, C; Cobb, K; Shelton, B; Coombs, W; Germolec, D

Published Date

  • September 2004

Published In

Volume / Issue

  • 42 / 1

Start / End Page

  • 85 - 93

PubMed ID

  • 15325401

Electronic International Standard Serial Number (EISSN)

  • 1574-695X

International Standard Serial Number (ISSN)

  • 0928-8244

Digital Object Identifier (DOI)

  • 10.1016/j.femsim.2004.06.004


  • eng