Animal models of sudden unexplained death.

Journal Article (Review;Journal Article)

The etiology of sudden infant death syndrome (SIDS) is unknown but thought to be multifactorial. Several animal models have been developed that induce death without pre-existing symptoms and with pathology similar to that seen in SIDS infants; however, the relevance of these animal models to the events leading to SIDS remains elusive, in part because animal models are as varied as the potential causes of SIDS. In addition, it is difficult to find an animal model that can accurately reflect the genetic, developmental and environmental risk factors for SIDS. Comparisons between species can prove difficult but animal models provide a useful tool for evaluating potential mechanisms related to sudden unexplained death. This review focuses on models developed to examine the association of infection and inflammation with mechanisms proposed to explain sudden unexplained death.

Full Text

Duke Authors

Cited Authors

  • Blood-Siegfried, J; Shelton, B

Published Date

  • September 2004

Published In

Volume / Issue

  • 42 / 1

Start / End Page

  • 34 - 41

PubMed ID

  • 15325395

Electronic International Standard Serial Number (EISSN)

  • 1574-695X

International Standard Serial Number (ISSN)

  • 0928-8244

Digital Object Identifier (DOI)

  • 10.1016/j.femsim.2004.06.009


  • eng