Animal models of soft-tissue sarcoma.

Journal Article (Journal Article;Review)

Soft-tissue sarcomas (STSs) are rare mesenchymal tumors that arise from muscle, fat and connective tissue. Currently, over 75 subtypes of STS are recognized. The rarity and heterogeneity of patient samples complicate clinical investigations into sarcoma biology. Model organisms might provide traction to our understanding and treatment of the disease. Over the past 10 years, many successful animal models of STS have been developed, primarily genetically engineered mice and zebrafish. These models are useful for studying the relevant oncogenes, signaling pathways and other cell changes involved in generating STSs. Recently, these model systems have become preclinical platforms in which to evaluate new drugs and treatment regimens. Thus, animal models are useful surrogates for understanding STS disease susceptibility and pathogenesis as well as for testing potential therapeutic strategies.

Full Text

Duke Authors

Cited Authors

  • Dodd, RD; Mito, JK; Kirsch, DG

Published Date

  • 2010

Published In

Volume / Issue

  • 3 / 9-10

Start / End Page

  • 557 - 566

PubMed ID

  • 20713645

Pubmed Central ID

  • PMC2931534

Electronic International Standard Serial Number (EISSN)

  • 1754-8411

Digital Object Identifier (DOI)

  • 10.1242/dmm.005223


  • eng

Conference Location

  • England