Multishot PROPELLER for high-field preclinical MRI.

Journal Article (Journal Article)

With the development of numerous mouse models of cancer, there is a tremendous need for an appropriate imaging technique to study the disease evolution. High-field T(2)-weighted imaging using PROPELLER (Periodically Rotated Overlapping ParallEL Lines with Enhanced Reconstruction) MRI meets this need. The two-shot PROPELLER technique presented here provides (a) high spatial resolution, (b) high contrast resolution, and (c) rapid and noninvasive imaging, which enables high-throughput, longitudinal studies in free-breathing mice. Unique data collection and reconstruction makes this method robust against motion artifacts. The two-shot modification introduced here retains more high-frequency information and provides higher signal-to-noise ratio than conventional single-shot PROPELLER, making this sequence feasible at high fields, where signal loss is rapid. Results are shown in a liver metastases model to demonstrate the utility of this technique in one of the more challenging regions of the mouse, which is the abdomen.

Full Text

Duke Authors

Cited Authors

  • Pandit, P; Qi, Y; Story, J; King, KF; Johnson, GA

Published Date

  • July 2010

Published In

Volume / Issue

  • 64 / 1

Start / End Page

  • 47 - 53

PubMed ID

  • 20572138

Pubmed Central ID

  • PMC3391749

Electronic International Standard Serial Number (EISSN)

  • 1522-2594

Digital Object Identifier (DOI)

  • 10.1002/mrm.22376


  • eng

Conference Location

  • United States