The relationship of manic episodes and drug abuse to sexual risk behavior in patients with co-occurring bipolar and substance use disorders: a 15-month prospective analysis.

Journal Article (Journal Article)

Risky sexual behavior is common among individuals with bipolar and substance use disorders. This 15-month prospective study examined the effects of between-subject differences and within-subject changes in mood symptoms and drug use on sexual risk behavior among 61 patients with both disorders. Participants completed five post-treatment follow-up assessments at 3-month intervals. Using a multivariate mixed-effects model analysis, more average weeks of mania (between-subject difference) was associated with greater sexual risk, but change in weeks of mania (within-subject change) was not; depression was unrelated to sexual risk. In addition, within-subject increases in days of cocaine use predicted increases in sexual risk. Results underscore the importance of substance abuse treatment and suggest that bipolar patients with active and/or recurrent mania are in need of targeted HIV prevention services. Further research is needed to test whether individual differences in impulsivity may explain the association between mania and sexual risk.

Full Text

Duke Authors

Cited Authors

  • Meade, CS; Fitzmaurice, GM; Sanchez, AK; Griffin, ML; McDonald, LJ; Weiss, RD

Published Date

  • November 2011

Published In

Volume / Issue

  • 15 / 8

Start / End Page

  • 1829 - 1833

PubMed ID

  • 20859672

Pubmed Central ID

  • PMC3191230

Electronic International Standard Serial Number (EISSN)

  • 1573-3254

Digital Object Identifier (DOI)

  • 10.1007/s10461-010-9814-9


  • eng

Conference Location

  • United States