Skip to main content

Use of oral ketoconazole to prevent postoperative erections following penile surgery.

Publication ,  Journal Article
Evans, KC; Peterson, AC; Ruiz, HE; Costabile, RA
Published in: Int J Impot Res
August 2004

Analgesics and topical agents ineffectively inhibit painful erections after penile and urethral surgery. Oral ketoconazole reversibly inhibits testosterone production and has been used empirically at our institution to decrease postoperative erections. We performed a retrospective review of 38 patients who had undergone penile and urethral reconstructive surgery. In all, 31 patients received 400 mg of ketoconazole three times daily for 10-14 days postoperatively (the study group) and seven patients did not receive ketoconazole (the control group). The incidence of postoperative erections, pain, side effects, surgical outcomes and patient satisfaction in each group were compared. Of the control group, 71% reported erections in the immediate postoperative period, and all these patients reported the erections were painful. Only 23% of the patient taking ketoconazole reported postoperative erections, and only 16% reported the erections were painful. We conclude that ketoconazole effectively prevents painful postoperative erections with minimal side effects.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Int J Impot Res

DOI

ISSN

0955-9930

Publication Date

August 2004

Volume

16

Issue

4

Start / End Page

346 / 349

Location

England

Related Subject Headings

  • Urologic Surgical Procedures, Male
  • Urethra
  • Treatment Outcome
  • Retrospective Studies
  • Postoperative Complications
  • Penis
  • Penile Erection
  • Pain, Postoperative
  • Obstetrics & Reproductive Medicine
  • Middle Aged
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Evans, K. C., Peterson, A. C., Ruiz, H. E., & Costabile, R. A. (2004). Use of oral ketoconazole to prevent postoperative erections following penile surgery. Int J Impot Res, 16(4), 346–349. https://doi.org/10.1038/sj.ijir.3901160
Evans, K. C., A. C. Peterson, H. E. Ruiz, and R. A. Costabile. “Use of oral ketoconazole to prevent postoperative erections following penile surgery.Int J Impot Res 16, no. 4 (August 2004): 346–49. https://doi.org/10.1038/sj.ijir.3901160.
Evans KC, Peterson AC, Ruiz HE, Costabile RA. Use of oral ketoconazole to prevent postoperative erections following penile surgery. Int J Impot Res. 2004 Aug;16(4):346–9.
Evans, K. C., et al. “Use of oral ketoconazole to prevent postoperative erections following penile surgery.Int J Impot Res, vol. 16, no. 4, Aug. 2004, pp. 346–49. Pubmed, doi:10.1038/sj.ijir.3901160.
Evans KC, Peterson AC, Ruiz HE, Costabile RA. Use of oral ketoconazole to prevent postoperative erections following penile surgery. Int J Impot Res. 2004 Aug;16(4):346–349.

Published In

Int J Impot Res

DOI

ISSN

0955-9930

Publication Date

August 2004

Volume

16

Issue

4

Start / End Page

346 / 349

Location

England

Related Subject Headings

  • Urologic Surgical Procedures, Male
  • Urethra
  • Treatment Outcome
  • Retrospective Studies
  • Postoperative Complications
  • Penis
  • Penile Erection
  • Pain, Postoperative
  • Obstetrics & Reproductive Medicine
  • Middle Aged