Radiation therapy in the treatment of cholangiocarcinoma.

Published

Journal Article (Review)

The prognosis of patients with biliary cancers is poor. Although surgery is potentially curative in selected patients, local recurrence is a common pattern of failure. Adjuvant or neoadjuvant radiation therapy improves local control and possibly survival. In locally advanced patients, radiation therapy provides palliation and may prolong survival. Concurrently administered chemotherapy may further enhance these results. Newer radiation therapy techniques, including intraluminal transcatheter brachytherapy, intraoperative radiation therapy, intensity-modulated radiation therapy, and three- and four-dimensional treatment planning, permit radiation dose escalation without significant increases in normal tissue toxicity, thereby increasing the effective radiation dose. Preliminary results of studies employing hepatic transplantation with radiation therapy are encouraging. Although these new approaches hold promise, the prognosis in patients with biliary cancers remains poor, and the integration of novel therapeutic strategies is indicated.

Full Text

Duke Authors

Cited Authors

  • Czito, BG; Anscher, MS; Willett, CG

Published Date

  • July 2006

Published In

Volume / Issue

  • 20 / 8

Start / End Page

  • 873 - 884

PubMed ID

  • 16922259

Pubmed Central ID

  • 16922259

International Standard Serial Number (ISSN)

  • 0890-9091

Language

  • eng

Conference Location

  • United States