Role of thymidine phosphorylase and orotate phosphoribosyltransferase mRNA expression and its ratio to dihydropyrimidine dehydrogenase in the prognosis and clinicopathological features of patients with pancreatic cancer.

Journal Article (Academic article)

BACKGROUND: Thymidine phosphorylase (TP), orotate phosphoribosyltransferase (OPRT), and dihydropyrimidine dehydrogenase (DPD) are important enzymes related to the metabolism of 5-fluorouracil and its derivatives. In this study, we analyzed the expression of these enzymes and evaluated the association between the expression of these enzymes and clinicopathological features and prognosis in patients with pancreatic cancer. METHODS: TP, OPRT, and DPD mRNA expressions were detected using a real-time reverse transcriptional-polymerase chain reaction method or by immunohistochemistry, using surgical specimens obtained from 25 patients with pancreatic cancer. RESULTS: TP mRNA expression was lower in cases with an alpha infiltration growth pattern than in cases with other infiltration growth patterns (P

Full Text

Duke Authors

Cited Authors

  • Miyake, K; Imura, S; Yoshizumi, T; Ikemoto, T; Morine, Y; Shimada, M

Published Date

  • April 2007

Published In

Volume / Issue

  • 12 / 2

Start / End Page

  • 111 - 119

International Standard Serial Number (ISSN)

  • 1341-9625

Digital Object Identifier (DOI)

  • 10.1007/s10147-006-0634-x

Language

  • English