[Pharmacokinetic and clinical studies on sulbactam/ampicillin in the pediatric field]


Journal Article (Academic article)

The new antibiotic, sulbactam/ampicillin (SBT/ABPC) was administered to 25 children. The results obtained are summarized as follows. 1. In 5 cases of children administered with SBT/ABPC (30 mg/kg) by intravenous drip infusion for 30 minutes, the mean values of T 1/2 (beta) were 0.94 hour (SBT) and 0.86 hour (ABPC) and the mean 6.5 hour urinary excretion rates were 64.2% and 42.9%, respectively. 2. The antibiotic was administered to a total of 25 patients with bronchopneumonia, pneumonia, bronchitis, cervical lymphadenitis, tonsillitis, streptococcal infection, urinary tract infection, felon, periappendicular abscess, sepsis or purulent meningitis. Response to the treatment were excellent in 17 cases, good in 7, fair in 1, and poor in none. The efficacy rate was 96%. From our results, this drug appears to be particularly effective against bronchopneumonia, bronchitis and urinary tract infection. 3. Eruption occurred in 1 of 25 patients and elevation of eosinophil, GOT/GPT, platelet in 3 and descent of WBC in 1 were observed, but these were transient. These results showed that SBT/ABPC is a drug which can be safely used in the pediatric field as well as for adults.

Duke Authors

Cited Authors

  • Ito, M; Ihara, T; Kamiya, H; Sakurai, M; Shimizu, S; Nishi, H; Kawaguchi, H; Yoshizumi, T; Inoue, M; Kojima, M

Published Date

  • March 1989

Published In

Volume / Issue

  • 42 / 3

Start / End Page

  • 651 - 661

International Standard Serial Number (ISSN)

  • 0368-2781


  • Japanese