Graft size, donor age, and patient status are the indicators of early graft function after living donor liver transplantation.

Journal Article (Academic article)

No reliable model for predicting early graft function and patient survival after living donor liver transplantation (LDLT) exists. The aim of this study was to establish a new formula for predicting early graft function and prognosis using technetium-99m galactosyl-human serum albumin (Tc-GSA) liver scintigraphy. The ratio of the hepatic uptake ratio of Tc-GSA to the clearance index of Tc-GSA (LHL/HH) was determined 7 days after LDLT. There were 22 patients with a ratio greater than 1.3 and 6 patients with a ratio less than 1.3. Graft function on the 14th postoperative day (POD) was compared between the 2 groups. A new formula to predict the LHL/HH score was established as follows: LHL/HH (predictive score) = 0.011 x graft weight (%) - 0.016 x donor age - 0.008 x Model for End-Stage Liver Disease score - 0.15 x shunt (if present) + 1.757 (r(2) = 0.497, P or = 1.3 were lower than those in the group with an LHL/HH score or = 1.3 (n = 86) were lower than those in the group with a score or = 1.3. In conclusion, this preoperative calculated LHL/HH score is correlated with graft function and short-term prognosis. Thus, this predictive model may allow transplant surgeons to use a living donor left lobe graft with greater confidence.

Full Text

Duke Authors

Cited Authors

  • Yoshizumi, T; Taketomi, A; Uchiyama, H; Harada, N; Kayashima, H; Yamashita, Y; Soejima, Y; Shimada, M; Maehara, Y

Published Date

  • July 2008

Published In

Volume / Issue

  • 14 / 7

Start / End Page

  • 1007 - 1013

International Standard Serial Number (ISSN)

  • 1527-6473

Digital Object Identifier (DOI)

  • 10.1002/lt.21462


  • English