Follicular lymphoid hyperplasia of the oral cavity representing progressive transformation of germinal center.

Journal Article (Academic article)

Follicular lymphoid hyperplasia (FLH) of the oral cavity is a rare and poorly understood lymphoproliferative disorder. We present a case of FLH of the oral cavity presenting with progressive transformation of germinal center (PTGC). The patient was a 49-year-old Japanese woman presenting with a hard mass in the right cheek. The resected specimen contained numerous lymphoid follicles with active germinal centers and a portion of the lymphoid follicles exhibited PTGC. The PTGCs contained a few large lymphoid cells resembling lymphocytic and histiocytic Reed-Sternberg cells of nodular lymphocyte-predominant Hodgkin lymphoma. The PTGC was surrounded by groups of epithelioid cells. In situ hybridization studies demonstrated strong expression of Epstein-Barr virus (EBV)-encoded small RNA in scattered large lymphoid cells in the PTGC. Although the etiology of FLH of the oral cavity remains unclear, the present case suggests that a subset of FLH of the oral cavity appears to be an EBV-associated lymphoproliferative disorder.

Full Text

Duke Authors

Cited Authors

  • Kojima, M; Nakamura, S; Iijima, M; Yoshizumi, T; Sakata, N; Masawa, N

Published Date

  • March 2005

Published In

Volume / Issue

  • 113 / 3

Start / End Page

  • 221 - 224

International Standard Serial Number (ISSN)

  • 0903-4641

Digital Object Identifier (DOI)

  • 10.1111/j.1600-0463.2005.apm1130311.x


  • English