Living donor liver transplantation for hepatitis B associated liver diseases: a 10-year experience in a single center.


Journal Article (Academic article)

BACKGROUND/AIMS: Hepatic failure associated with hepatitis B virus (HBV) is one of the main indications for living donor liver transplantation (LDLT). METHODOLOGY: Twenty-nine LDLTs, including liver cirrhosis due to HBV (LC-B) (n = 17) and fulminant hepatitis B (FH-B) (n = 12) were reviewed. Prophylaxis for reinfection was performed with a combination of lamivudine, or hepatitis B immune globulin (HBIG) or adefovir, depending on the viral status. The changes in serological markers, recurrence and survival rate were examined. RESULTS: There were 3 patients with re-emergencies of HBV surface antigen (HBsAg): suspension of HBIG for giving vaccination for HBV (n = 1), HBsAg positive donor (n = 1) and non-compliance for HBIG (n = 1). All patients with YMDD mutants (n = 9), except the case with HBsAg positive donor (n = 1), were successfully protected by the triple therapy of lamivudine, adefovir and HBIG. No graft loss was due to the recurrence of HBV. CONCLUSION: The basic strategy using a combination of HBIG and antiviral agents gave acceptable long-term outcomes for LDLT for HBV associated liver diseases. The close monitoring of HBV viral status after transplantation is still crucial in managing these patients.

Duke Authors

Cited Authors

  • Ikegami, T; Soejima, Y; Ohta, R; Taketomi, A; Yoshizumi, T; Harada, N; Kayashima, H; Maehara, Y

Published Date

  • January 2009

Published In

Volume / Issue

  • 55 / 85

Start / End Page

  • 1445 - 1449

International Standard Serial Number (ISSN)

  • 0172-6390


  • English