Cancer and thrombosis: back to the future renewed interest in an old problem.


Journal Article

Cancer patients are at increased risk for thromboembolic complications due to the release of procoagulants, compression or invasion of blood vessels and the reduced mobility associated with cancer and cancer treatment. This has led to recommendations for thromboprophylaxis in hospitalized medical and surgical cancer patients and extended prophylaxis in cancer patients experiencing a venous thromboembolism. Routine prophylactic anticoagulation is not currently recommended in ambulatory cancer patients except in very high risk settings. Another area of increasing research interest is the potential role of anticoagulants on tumor growth, invasiveness and metastasis. Several randomized controlled trials have suggested a potential benefit of anticoagulation on cancer patient survival. Additional investigation into these and related questions should represent a high priority area for future basic and translational cancer research.

Full Text

Duke Authors

Cited Authors

  • Lyman, GH; Khorana, AA; Kuderer, NM; Lee, AY

Published Date

  • June 2009

Published In

Volume / Issue

  • 27 / 5

Start / End Page

  • 472 - 473

PubMed ID

  • 19479483

Pubmed Central ID

  • 19479483

Electronic International Standard Serial Number (EISSN)

  • 1532-4192

Digital Object Identifier (DOI)

  • 10.1080/07357900902996441


  • eng

Conference Location

  • England