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Parathyroid hormone secretion and target organ response in experimental acute pancreatitis.

Publication ,  Journal Article
Schachter, PP; Christy, MD; Lobaugh, B; Leight, GS
Published in: Arch Surg
February 1991

To determine changes in parathyroid hormone secretion and target organ response caused by acute pancreatitis before the development of systemic toxic conditions, experimental acute pancreatitis was induced in rats with a choline-deficient, ethionine-supplemented diet. After 7 days, the rats were weighed and bled, and one kidney was assayed for 25-hydroxyvitamin D1 hydroxylase activity. Several manifestations of pancreatitis were observed in rats given the diet: weight loss (from 29.6 to 26.3 g vs that for control rats, from 29 to 52.8 g) and lower dietary intake (15.5 vs 47 g per rat per 7 days). Serum amylase levels fell from 1794 to 350 U/L in rats given the choline-deficient, ethionine-supplemented diet compared with levels of 1800 to 2100 U/L in control rats. The pancreases of rats given the choline-deficient, ethionine-supplemented diet showed degeneration, necrosis, and hemorrhaging. Serum levels of calcium, phosphorus, chloride, and parathyroid hormone did not change significantly throughout the experiment. Renal 25-hydroxyvitamin D1 hydroxylase activity was higher than in control rats (8.9 +/- 0.8 vs 7.6 +/- 0.6 fmol/mg of kidney per minute). Acute pancreatitis in this experimental animal model does not alter serum levels of calcium and parathyroid hormone or reduce target organ responsiveness to the hormone.

Duke Scholars

Published In

Arch Surg

DOI

ISSN

0004-0010

Publication Date

February 1991

Volume

126

Issue

2

Start / End Page

139 / 142

Location

United States

Related Subject Headings

  • Weight Loss
  • Surgery
  • Spectrophotometry
  • Rats, Inbred F344
  • Rats
  • Phosphorus
  • Parathyroid Hormone
  • Pancreatitis
  • Necrosis
  • Male
 

Citation

APA
Chicago
ICMJE
MLA
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Schachter, P. P., Christy, M. D., Lobaugh, B., & Leight, G. S. (1991). Parathyroid hormone secretion and target organ response in experimental acute pancreatitis. Arch Surg, 126(2), 139–142. https://doi.org/10.1001/archsurg.1991.01410260023003
Schachter, P. P., M. D. Christy, B. Lobaugh, and G. S. Leight. “Parathyroid hormone secretion and target organ response in experimental acute pancreatitis.Arch Surg 126, no. 2 (February 1991): 139–42. https://doi.org/10.1001/archsurg.1991.01410260023003.
Schachter PP, Christy MD, Lobaugh B, Leight GS. Parathyroid hormone secretion and target organ response in experimental acute pancreatitis. Arch Surg. 1991 Feb;126(2):139–42.
Schachter, P. P., et al. “Parathyroid hormone secretion and target organ response in experimental acute pancreatitis.Arch Surg, vol. 126, no. 2, Feb. 1991, pp. 139–42. Pubmed, doi:10.1001/archsurg.1991.01410260023003.
Schachter PP, Christy MD, Lobaugh B, Leight GS. Parathyroid hormone secretion and target organ response in experimental acute pancreatitis. Arch Surg. 1991 Feb;126(2):139–142.

Published In

Arch Surg

DOI

ISSN

0004-0010

Publication Date

February 1991

Volume

126

Issue

2

Start / End Page

139 / 142

Location

United States

Related Subject Headings

  • Weight Loss
  • Surgery
  • Spectrophotometry
  • Rats, Inbred F344
  • Rats
  • Phosphorus
  • Parathyroid Hormone
  • Pancreatitis
  • Necrosis
  • Male