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Predictors of variation in serum IGF1 and IGFBP3 levels in healthy African American and white men.

Publication ,  Journal Article
Hoyo, C; Grubber, J; Demark-Wahnefried, W; Lobaugh, B; Jeffreys, AS; Grambow, SC; Marks, JR; Keku, TO; Walther, PJ; Schildkraut, JM
Published in: J Natl Med Assoc
July 2009

BACKGROUND: Individual variation in circulating insulinlike growth factor-1 (IGF1) and its major binding protein, insulinlike growth factor binding protein-3 (IGFBP3), have been etiologically linked to several chronic diseases, including some cancers. Factors associated with variation in circulating levels of these peptide hormones remain unclear. METHODS: Multiple linear regression models were used to determine the extent to which sociodemographic characteristics, lifestyle factors, personal and family history of chronic disease, and common genetic variants, the (CA)n repeat polymorphism in the IGF1 promoter and the IGFBP3-202 A/C polymorphism (rs2854744) predict variation in IGF1 or IGFBP3 serum levels in 33 otherwise healthy African American and 37 white males recruited from Durham Veterans Administration Medical Center. RESULTS: Predictors of serum IGF1, IGFBP3, and the IGF1:IGFBP3 molar ratio varied by race. In African Americans, 17% and 28% of the variation in serum IGF1 and the IGF1:IGFBP3 molar ratio, were explained by cigarette smoking and carrying the IGF1 (CA)19 repeat allele, respectively. Not carrying at least 1 IGF1 (CA)19 repeat allele and a high body mass index explained 8% and 14%, respectively, of the variation IGFBP3 levels. These factors did not predict variation of these peptides in whites. CONCLUSION: If successfully replicated in larger studies, these findings would add to recent evidence, suggesting known genetic and lifestyle chronic disease risk factors influence IGF1 and IGFBP3 circulating levels differently in African Americans and whites.

Duke Scholars

Published In

J Natl Med Assoc

DOI

ISSN

0027-9684

Publication Date

July 2009

Volume

101

Issue

7

Start / End Page

711 / 716

Location

United States

Related Subject Headings

  • White People
  • United States
  • Socioeconomic Factors
  • Smoking
  • Public Health
  • Promoter Regions, Genetic
  • Predictive Value of Tests
  • Male
  • Linear Models
  • Life Style
 

Citation

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ICMJE
MLA
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Hoyo, C., Grubber, J., Demark-Wahnefried, W., Lobaugh, B., Jeffreys, A. S., Grambow, S. C., … Schildkraut, J. M. (2009). Predictors of variation in serum IGF1 and IGFBP3 levels in healthy African American and white men. J Natl Med Assoc, 101(7), 711–716. https://doi.org/10.1016/s0027-9684(15)30981-0
Hoyo, Cathrine, Janet Grubber, Wendy Demark-Wahnefried, Bruce Lobaugh, Amy S. Jeffreys, Steven C. Grambow, Jeffrey R. Marks, Temitope O. Keku, Phillip J. Walther, and Joellen M. Schildkraut. “Predictors of variation in serum IGF1 and IGFBP3 levels in healthy African American and white men.J Natl Med Assoc 101, no. 7 (July 2009): 711–16. https://doi.org/10.1016/s0027-9684(15)30981-0.
Hoyo C, Grubber J, Demark-Wahnefried W, Lobaugh B, Jeffreys AS, Grambow SC, et al. Predictors of variation in serum IGF1 and IGFBP3 levels in healthy African American and white men. J Natl Med Assoc. 2009 Jul;101(7):711–6.
Hoyo, Cathrine, et al. “Predictors of variation in serum IGF1 and IGFBP3 levels in healthy African American and white men.J Natl Med Assoc, vol. 101, no. 7, July 2009, pp. 711–16. Pubmed, doi:10.1016/s0027-9684(15)30981-0.
Hoyo C, Grubber J, Demark-Wahnefried W, Lobaugh B, Jeffreys AS, Grambow SC, Marks JR, Keku TO, Walther PJ, Schildkraut JM. Predictors of variation in serum IGF1 and IGFBP3 levels in healthy African American and white men. J Natl Med Assoc. 2009 Jul;101(7):711–716.
Journal cover image

Published In

J Natl Med Assoc

DOI

ISSN

0027-9684

Publication Date

July 2009

Volume

101

Issue

7

Start / End Page

711 / 716

Location

United States

Related Subject Headings

  • White People
  • United States
  • Socioeconomic Factors
  • Smoking
  • Public Health
  • Promoter Regions, Genetic
  • Predictive Value of Tests
  • Male
  • Linear Models
  • Life Style