Vitamin D receptor alleles do not correlate with bone mineral density in premenopausal Caucasian women from the southeastern United States.

Published

Journal Article

Genetic factors are important in determining peak bone density. Recent studies indicate that polymorphisms of the vitamin D receptor (VDR) may account for much of the genetic contribution to bone density, and VDR genotype may be useful to predict the risk of developing osteoporosis. However, the association between VDR genotype and bone mineral density (BMD) has not been observed in all populations. We determined VDR genotype in 69 healthy premenopausal Caucasion women from the southeastern United States and measured BMD at the lumbar spine (anterior-posterior [AP] and lateral views) and proximal femur. We found no association between VDR genotype and BMD at any site. Our results indicate that in this population, VDR genotype does not predict peak bone density and should not be used to predict the risk of developing osteoporosis.

Full Text

Duke Authors

Cited Authors

  • Alahari, KD; Lobaugh, B; Econs, MJ

Published Date

  • February 1997

Published In

Volume / Issue

  • 46 / 2

Start / End Page

  • 224 - 226

PubMed ID

  • 9030833

Pubmed Central ID

  • 9030833

Electronic International Standard Serial Number (EISSN)

  • 1532-8600

International Standard Serial Number (ISSN)

  • 0026-0495

Digital Object Identifier (DOI)

  • 10.1016/s0026-0495(97)90306-1

Language

  • eng