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Anchorage-independent cell growth signature identifies tumors with metastatic potential.

Publication ,  Journal Article
Mori, S; Chang, JT; Andrechek, ER; Matsumura, N; Baba, T; Yao, G; Kim, JW; Gatza, M; Murphy, S; Nevins, JR
Published in: Oncogene
August 6, 2009

The oncogenic phenotype is complex, resulting from the accumulation of multiple somatic mutations that lead to the deregulation of growth regulatory and cell fate controlling activities and pathways. The ability to dissect this complexity, so as to reveal discrete aspects of the biology underlying the oncogenic phenotype, is critical to understanding the various mechanisms of disease as well as to reveal opportunities for novel therapeutic strategies. Previous work has characterized the process of anchorage-independent growth of cancer cells in vitro as a key aspect of the tumor phenotype, particularly with respect to metastatic potential. Nevertheless, it remains a major challenge to translate these cell biology findings into the context of human tumors. We previously used DNA microarray assays to develop expression signatures, which have the capacity to identify subtle distinctions in biological states and can be used to connect in vitro and in vivo states. Here we describe the development of a signature of anchorage-independent growth, show that the signature exhibits characteristics of deregulated mitochondrial function and then demonstrate that the signature identifies human tumors with the potential for metastasis.

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Published In

Oncogene

DOI

EISSN

1476-5594

Publication Date

August 6, 2009

Volume

28

Issue

31

Start / End Page

2796 / 2805

Location

England

Related Subject Headings

  • Tumor Stem Cell Assay
  • Regression Analysis
  • Prognosis
  • Phenotype
  • Oncology & Carcinogenesis
  • Oligonucleotide Array Sequence Analysis
  • Neoplasms
  • Neoplasm Metastasis
  • Mice
  • Humans
 

Citation

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Mori, S., Chang, J. T., Andrechek, E. R., Matsumura, N., Baba, T., Yao, G., … Nevins, J. R. (2009). Anchorage-independent cell growth signature identifies tumors with metastatic potential. Oncogene, 28(31), 2796–2805. https://doi.org/10.1038/onc.2009.139
Mori, S., J. T. Chang, E. R. Andrechek, N. Matsumura, T. Baba, G. Yao, J. W. Kim, M. Gatza, S. Murphy, and J. R. Nevins. “Anchorage-independent cell growth signature identifies tumors with metastatic potential.Oncogene 28, no. 31 (August 6, 2009): 2796–2805. https://doi.org/10.1038/onc.2009.139.
Mori S, Chang JT, Andrechek ER, Matsumura N, Baba T, Yao G, et al. Anchorage-independent cell growth signature identifies tumors with metastatic potential. Oncogene. 2009 Aug 6;28(31):2796–805.
Mori, S., et al. “Anchorage-independent cell growth signature identifies tumors with metastatic potential.Oncogene, vol. 28, no. 31, Aug. 2009, pp. 2796–805. Pubmed, doi:10.1038/onc.2009.139.
Mori S, Chang JT, Andrechek ER, Matsumura N, Baba T, Yao G, Kim JW, Gatza M, Murphy S, Nevins JR. Anchorage-independent cell growth signature identifies tumors with metastatic potential. Oncogene. 2009 Aug 6;28(31):2796–2805.

Published In

Oncogene

DOI

EISSN

1476-5594

Publication Date

August 6, 2009

Volume

28

Issue

31

Start / End Page

2796 / 2805

Location

England

Related Subject Headings

  • Tumor Stem Cell Assay
  • Regression Analysis
  • Prognosis
  • Phenotype
  • Oncology & Carcinogenesis
  • Oligonucleotide Array Sequence Analysis
  • Neoplasms
  • Neoplasm Metastasis
  • Mice
  • Humans