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Chemotherapy and high dose radiotherapy followed by resection for locally advanced nonsmall cell lung cancers.

Publication ,  Journal Article
Shaikh, AY; Haraf, DJ; Salama, JK; Salgia, R; Hoffman, PC; Ferguson, MK; Connell, PP
Published in: Am J Clin Oncol
June 2007

OBJECTIVES: For locally advanced but technically operable nonsmall cell lung cancer (NSCLC), neoadjuvant chemoradiotherapy is frequently used. Ideal radiotherapy dose in this context is unclear. MATERIALS AND METHODS: Twenty-six NSCLC patients with N2 disease were retrospectively reviewed. All received preoperative concurrent platinum-based chemoradiotherapy. Gross tumor volumes received a median of 58 Gy (range, 50-60 Gy). RESULTS: Two patients experienced major complications and died, resulting in a postoperative mortality rate of 7.7%. Three patients (11.5%) had minor complications. Pathologic specimens revealed downstaging in 76.9% of patients. The pathologic complete response (CR) rate was 34.6%. Downstaging of nodes was observed in 20 of 26 patients. With a median follow-up of 18.3 months, the 1- and 3-year actuarial survival rates were 80.2% and 45.7%, respectively. The 1- and 3-year actuarial disease-free survival (DFS) rates were 76.9% and 37.3%, respectively. Patients experiencing mediastinal downstaging had better DFS rates, relative to patients that did not (18-month DFS = 79.2% vs. 0%; P = 0.0001). Differences in RT dose (50-60 Gy) and types of chemotherapeutic regimens did not significantly impact pathologic downstaging rates, CR rates, DFS, or survival. DISCUSSION: Neoadjuvant chemotherapy with high-dose concurrent RT is well tolerated and results in favorable outcomes.

Duke Scholars

Published In

Am J Clin Oncol

DOI

EISSN

1537-453X

Publication Date

June 2007

Volume

30

Issue

3

Start / End Page

258 / 263

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Retrospective Studies
  • Radiotherapy
  • Pneumonectomy
  • Platinum Compounds
  • Oncology & Carcinogenesis
  • Neoplasm Staging
  • Neoadjuvant Therapy
  • Middle Aged
  • Male
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Shaikh, A. Y., Haraf, D. J., Salama, J. K., Salgia, R., Hoffman, P. C., Ferguson, M. K., & Connell, P. P. (2007). Chemotherapy and high dose radiotherapy followed by resection for locally advanced nonsmall cell lung cancers. Am J Clin Oncol, 30(3), 258–263. https://doi.org/10.1097/01.coc.0000258109.83083.78
Shaikh, Arif Y., Daniel J. Haraf, Joseph K. Salama, Ravi Salgia, Philip C. Hoffman, Mark K. Ferguson, and Philip P. Connell. “Chemotherapy and high dose radiotherapy followed by resection for locally advanced nonsmall cell lung cancers.Am J Clin Oncol 30, no. 3 (June 2007): 258–63. https://doi.org/10.1097/01.coc.0000258109.83083.78.
Shaikh AY, Haraf DJ, Salama JK, Salgia R, Hoffman PC, Ferguson MK, et al. Chemotherapy and high dose radiotherapy followed by resection for locally advanced nonsmall cell lung cancers. Am J Clin Oncol. 2007 Jun;30(3):258–63.
Shaikh, Arif Y., et al. “Chemotherapy and high dose radiotherapy followed by resection for locally advanced nonsmall cell lung cancers.Am J Clin Oncol, vol. 30, no. 3, June 2007, pp. 258–63. Pubmed, doi:10.1097/01.coc.0000258109.83083.78.
Shaikh AY, Haraf DJ, Salama JK, Salgia R, Hoffman PC, Ferguson MK, Connell PP. Chemotherapy and high dose radiotherapy followed by resection for locally advanced nonsmall cell lung cancers. Am J Clin Oncol. 2007 Jun;30(3):258–263.

Published In

Am J Clin Oncol

DOI

EISSN

1537-453X

Publication Date

June 2007

Volume

30

Issue

3

Start / End Page

258 / 263

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Retrospective Studies
  • Radiotherapy
  • Pneumonectomy
  • Platinum Compounds
  • Oncology & Carcinogenesis
  • Neoplasm Staging
  • Neoadjuvant Therapy
  • Middle Aged
  • Male