Skip to main content
Journal cover image

Concurrent chemotherapy and re-irradiation for locoregionally recurrent head and neck cancer.

Publication ,  Journal Article
Salama, JK; Vokes, EE
Published in: Semin Oncol
June 2008

Recurrent and second primary tumors arising within a previously radiated head and neck volume represent a difficult clinical scenario to manage. For patients who have resectable disease, surgery is the standard treatment. Chemotherapy is the standard for patients with unresectable or metastatic disease but offers no chance for cure. Re-irradiation (RRT) with concurrent chemotherapy is a potentially curative treatment option. In this article, we will review the basis for current chemoradiotherapy (CRT) regimens used in previously radiated patients, focusing on outcome and toxicity. Additionally, we will review radiotherapy techniques used in this setting and highlight the differences between definitive radiotherapy and RRT. Controversies, such as the utility of chemotherapy and RRT following surgical salvage, will be addressed. Finally, we will review investigations seeking to improve the therapeutic outcomes of patients treated with chemotherapy and RRT.

Duke Scholars

Published In

Semin Oncol

DOI

ISSN

0093-7754

Publication Date

June 2008

Volume

35

Issue

3

Start / End Page

251 / 261

Location

United States

Related Subject Headings

  • Salvage Therapy
  • Radiotherapy
  • Oncology & Carcinogenesis
  • Neoplasms, Second Primary
  • Neoplasm Recurrence, Local
  • Humans
  • Head and Neck Neoplasms
  • Combined Modality Therapy
  • Chemotherapy, Adjuvant
  • 3211 Oncology and carcinogenesis
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Salama, J. K., & Vokes, E. E. (2008). Concurrent chemotherapy and re-irradiation for locoregionally recurrent head and neck cancer. Semin Oncol, 35(3), 251–261. https://doi.org/10.1053/j.seminoncol.2008.03.010
Salama, Joseph K., and Everett E. Vokes. “Concurrent chemotherapy and re-irradiation for locoregionally recurrent head and neck cancer.Semin Oncol 35, no. 3 (June 2008): 251–61. https://doi.org/10.1053/j.seminoncol.2008.03.010.
Salama, Joseph K., and Everett E. Vokes. “Concurrent chemotherapy and re-irradiation for locoregionally recurrent head and neck cancer.Semin Oncol, vol. 35, no. 3, June 2008, pp. 251–61. Pubmed, doi:10.1053/j.seminoncol.2008.03.010.
Journal cover image

Published In

Semin Oncol

DOI

ISSN

0093-7754

Publication Date

June 2008

Volume

35

Issue

3

Start / End Page

251 / 261

Location

United States

Related Subject Headings

  • Salvage Therapy
  • Radiotherapy
  • Oncology & Carcinogenesis
  • Neoplasms, Second Primary
  • Neoplasm Recurrence, Local
  • Humans
  • Head and Neck Neoplasms
  • Combined Modality Therapy
  • Chemotherapy, Adjuvant
  • 3211 Oncology and carcinogenesis