Concurrent chemotherapy and re-irradiation for locoregionally recurrent head and neck cancer.


Journal Article (Review)

Recurrent and second primary tumors arising within a previously radiated head and neck volume represent a difficult clinical scenario to manage. For patients who have resectable disease, surgery is the standard treatment. Chemotherapy is the standard for patients with unresectable or metastatic disease but offers no chance for cure. Re-irradiation (RRT) with concurrent chemotherapy is a potentially curative treatment option. In this article, we will review the basis for current chemoradiotherapy (CRT) regimens used in previously radiated patients, focusing on outcome and toxicity. Additionally, we will review radiotherapy techniques used in this setting and highlight the differences between definitive radiotherapy and RRT. Controversies, such as the utility of chemotherapy and RRT following surgical salvage, will be addressed. Finally, we will review investigations seeking to improve the therapeutic outcomes of patients treated with chemotherapy and RRT.

Full Text

Duke Authors

Cited Authors

  • Salama, JK; Vokes, EE

Published Date

  • June 2008

Published In

Volume / Issue

  • 35 / 3

Start / End Page

  • 251 - 261

PubMed ID

  • 18544440

Pubmed Central ID

  • 18544440

International Standard Serial Number (ISSN)

  • 0093-7754

Digital Object Identifier (DOI)

  • 10.1053/j.seminoncol.2008.03.010


  • eng

Conference Location

  • United States