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Chemoradiotherapy for locoregionally advanced squamous cell carcinoma of the base of tongue.

Publication ,  Journal Article
Pederson, AW; Haraf, DJ; Witt, M-E; Stenson, KM; Vokes, EE; Blair, EA; Salama, JK
Published in: Head Neck
November 2010

BACKGROUND: Our aim was to report the outcomes of base of tongue cancers treated with chemoradiotherapy. METHODS: Between 1990 and 2004, 127 patients with stage III or IV base of tongue cancer were treated with chemoradiotherapy on protocol. Indications included nodal involvement, T3/T4 tumors, positive margins, those patients refusing surgery, or were medically inoperable. The most common regimen was paclitaxel (100 mg/m2 on day 1), infusional 5-fluorouracil (600 mg/m2/day × 5 days), hydroxyurea (500 mg prescribed orally [PO] 2 × daily [BID]), and 1.5 Gy twice daily irradiation followed by a 9-day break without treatment. RESULTS: Median follow-up was 51 months. The median dose to gross tumor was 72.5 Gy (range, 40-75.5 Gy). Five-year locoregional progression-free survival, overall survival, and disease-free survival was 87.0%, 58.2%, and 46.0%, respectively. CONCLUSION: Concurrent chemoradiotherapy results in promising locoregional control for base of tongue cancer. As distant relapse was common, further investigation of systemic therapy with novel agents may be warranted.

Duke Scholars

Published In

Head Neck

DOI

EISSN

1097-0347

Publication Date

November 2010

Volume

32

Issue

11

Start / End Page

1519 / 1527

Location

United States

Related Subject Headings

  • Tongue Neoplasms
  • Recombinant Proteins
  • Radiotherapy, Intensity-Modulated
  • Radiotherapy, Adjuvant
  • Radiotherapy Dosage
  • Paclitaxel
  • Otorhinolaryngology
  • Neck Dissection
  • Middle Aged
  • Male
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Pederson, A. W., Haraf, D. J., Witt, M.-E., Stenson, K. M., Vokes, E. E., Blair, E. A., & Salama, J. K. (2010). Chemoradiotherapy for locoregionally advanced squamous cell carcinoma of the base of tongue. Head Neck, 32(11), 1519–1527. https://doi.org/10.1002/hed.21360
Pederson, Aaron W., Daniel J. Haraf, Mary-Ellyn Witt, Kerstin M. Stenson, Everett E. Vokes, Elizabeth A. Blair, and Joseph K. Salama. “Chemoradiotherapy for locoregionally advanced squamous cell carcinoma of the base of tongue.Head Neck 32, no. 11 (November 2010): 1519–27. https://doi.org/10.1002/hed.21360.
Pederson AW, Haraf DJ, Witt M-E, Stenson KM, Vokes EE, Blair EA, et al. Chemoradiotherapy for locoregionally advanced squamous cell carcinoma of the base of tongue. Head Neck. 2010 Nov;32(11):1519–27.
Pederson, Aaron W., et al. “Chemoradiotherapy for locoregionally advanced squamous cell carcinoma of the base of tongue.Head Neck, vol. 32, no. 11, Nov. 2010, pp. 1519–27. Pubmed, doi:10.1002/hed.21360.
Pederson AW, Haraf DJ, Witt M-E, Stenson KM, Vokes EE, Blair EA, Salama JK. Chemoradiotherapy for locoregionally advanced squamous cell carcinoma of the base of tongue. Head Neck. 2010 Nov;32(11):1519–1527.
Journal cover image

Published In

Head Neck

DOI

EISSN

1097-0347

Publication Date

November 2010

Volume

32

Issue

11

Start / End Page

1519 / 1527

Location

United States

Related Subject Headings

  • Tongue Neoplasms
  • Recombinant Proteins
  • Radiotherapy, Intensity-Modulated
  • Radiotherapy, Adjuvant
  • Radiotherapy Dosage
  • Paclitaxel
  • Otorhinolaryngology
  • Neck Dissection
  • Middle Aged
  • Male