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Evaluation of patients after extraperitoneal lymph node dissection and subsequent radiotherapy for cervical cancer.

Publication ,  Journal Article
Hasenburg, A; Salama, JK; Van, TJ; Amosson, C; Chiu, JK; Kieback, DG
Published in: Gynecol Oncol
February 2002

OBJECTIVE: The presence of nodal metastases is the most important prognostic factor in cervical cancer. To adjust our therapy based on the true extent of the patient's disease, we performed an extraperitoneal lymph node dissection (EPLND) in all patients with cervical cancer prior to radiotherapy (RT) or radical hysterectomy. METHODS: Thirty-three patients with carcinoma of the cervix underwent EPLND. The value of this procedure as a diagnostic tool for monitoring the extension of the disease was determined. Additionally, EPLND/RT-associated treatment complications were monitored. RESULTS: The combined treatment approach of EPLND with RT or chemotherapy/RT was without major complications. Nineteen patients showed a temperature elevation, but only one patient had a fever of greater than 39.0 degrees C. Fourteen (48.3%) of 29 patients experienced some degree of proctitis or diarrhea and 3 (10.3%) experienced cystitis during the course of RT. No grade 3 or 4 acute or late genitourinary or gastrointestinal toxicities were noted. EPLND changed the clinical management for 6 patients from a radical hysterectomy to RT and for 7 patients from standard-field RT to extended-field RT. Without EPLND these 7 patients would have received RT with standard pelvic fields that would not have treated involved lymph node areas at high risk for subsequent failure. CONCLUSION: Thirteen (44.8%) of 29 patients received a different treatment than would otherwise have been administered with standard treatment planning. Therefore, we suggest that EPLND should be performed in all patients with cervical cancer prior to radical surgery or RT.

Duke Scholars

Published In

Gynecol Oncol

DOI

ISSN

0090-8258

Publication Date

February 2002

Volume

84

Issue

2

Start / End Page

321 / 326

Location

United States

Related Subject Headings

  • Uterine Cervical Neoplasms
  • Time Factors
  • Oncology & Carcinogenesis
  • Neoplasm Staging
  • Middle Aged
  • Lymph Nodes
  • Lymph Node Excision
  • Hysterectomy
  • Humans
  • Female
 

Citation

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Hasenburg, A., Salama, J. K., Van, T. J., Amosson, C., Chiu, J. K., & Kieback, D. G. (2002). Evaluation of patients after extraperitoneal lymph node dissection and subsequent radiotherapy for cervical cancer. Gynecol Oncol, 84(2), 321–326. https://doi.org/10.1006/gyno.2001.6528
Hasenburg, Annette, Joseph K. Salama, T John Van, Chad Amosson, J Kam Chiu, and Dirk G. Kieback. “Evaluation of patients after extraperitoneal lymph node dissection and subsequent radiotherapy for cervical cancer.Gynecol Oncol 84, no. 2 (February 2002): 321–26. https://doi.org/10.1006/gyno.2001.6528.
Hasenburg A, Salama JK, Van TJ, Amosson C, Chiu JK, Kieback DG. Evaluation of patients after extraperitoneal lymph node dissection and subsequent radiotherapy for cervical cancer. Gynecol Oncol. 2002 Feb;84(2):321–6.
Hasenburg, Annette, et al. “Evaluation of patients after extraperitoneal lymph node dissection and subsequent radiotherapy for cervical cancer.Gynecol Oncol, vol. 84, no. 2, Feb. 2002, pp. 321–26. Pubmed, doi:10.1006/gyno.2001.6528.
Hasenburg A, Salama JK, Van TJ, Amosson C, Chiu JK, Kieback DG. Evaluation of patients after extraperitoneal lymph node dissection and subsequent radiotherapy for cervical cancer. Gynecol Oncol. 2002 Feb;84(2):321–326.
Journal cover image

Published In

Gynecol Oncol

DOI

ISSN

0090-8258

Publication Date

February 2002

Volume

84

Issue

2

Start / End Page

321 / 326

Location

United States

Related Subject Headings

  • Uterine Cervical Neoplasms
  • Time Factors
  • Oncology & Carcinogenesis
  • Neoplasm Staging
  • Middle Aged
  • Lymph Nodes
  • Lymph Node Excision
  • Hysterectomy
  • Humans
  • Female