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Oxytocin exposure during labor among women with postpartum hemorrhage secondary to uterine atony.

Publication ,  Journal Article
Grotegut, CA; Paglia, MJ; Johnson, LNC; Thames, B; James, AH
Published in: Am J Obstet Gynecol
January 2011

OBJECTIVE: We sought to determine if women with severe postpartum hemorrhage (PPH) secondary to uterine atony received greater amounts of oxytocin during labor compared to women without PPH. STUDY DESIGN: Subjects with severe PPH secondary to uterine atony, who received a blood transfusion, were compared to matched controls. Total oxytocin exposure was calculated as the area under the concentration curve (mU/min*min). Variables were compared using paired t test, χ², and logistic regression. RESULTS: Women with severe PPH had a mean oxytocin area under the curve of 10,054 mU compared to 3762 mU in controls (P < .001). After controlling for race, body mass index, admission hematocrit, induction status, magnesium therapy, and chorioamnionitis using logistic regression, oxytocin area under the curve continued to predict severe PPH. CONCLUSION: Women with severe PPH secondary to uterine atony were exposed to significantly more oxytocin during labor compared to matched controls.

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Published In

Am J Obstet Gynecol

DOI

EISSN

1097-6868

Publication Date

January 2011

Volume

204

Issue

1

Start / End Page

56.e1 / 56.e6

Location

United States

Related Subject Headings

  • Uterine Inertia
  • Pregnancy
  • Postpartum Hemorrhage
  • Oxytocin
  • Oxytocics
  • Obstetrics & Reproductive Medicine
  • Logistic Models
  • Humans
  • Hematocrit
  • Female
 

Citation

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Grotegut, C. A., Paglia, M. J., Johnson, L. N. C., Thames, B., & James, A. H. (2011). Oxytocin exposure during labor among women with postpartum hemorrhage secondary to uterine atony. Am J Obstet Gynecol, 204(1), 56.e1-56.e6. https://doi.org/10.1016/j.ajog.2010.08.023
Grotegut, Chad A., Michael J. Paglia, Lauren N. C. Johnson, Betty Thames, and Andra H. James. “Oxytocin exposure during labor among women with postpartum hemorrhage secondary to uterine atony.Am J Obstet Gynecol 204, no. 1 (January 2011): 56.e1-56.e6. https://doi.org/10.1016/j.ajog.2010.08.023.
Grotegut CA, Paglia MJ, Johnson LNC, Thames B, James AH. Oxytocin exposure during labor among women with postpartum hemorrhage secondary to uterine atony. Am J Obstet Gynecol. 2011 Jan;204(1):56.e1-56.e6.
Grotegut, Chad A., et al. “Oxytocin exposure during labor among women with postpartum hemorrhage secondary to uterine atony.Am J Obstet Gynecol, vol. 204, no. 1, Jan. 2011, pp. 56.e1-56.e6. Pubmed, doi:10.1016/j.ajog.2010.08.023.
Grotegut CA, Paglia MJ, Johnson LNC, Thames B, James AH. Oxytocin exposure during labor among women with postpartum hemorrhage secondary to uterine atony. Am J Obstet Gynecol. 2011 Jan;204(1):56.e1-56.e6.
Journal cover image

Published In

Am J Obstet Gynecol

DOI

EISSN

1097-6868

Publication Date

January 2011

Volume

204

Issue

1

Start / End Page

56.e1 / 56.e6

Location

United States

Related Subject Headings

  • Uterine Inertia
  • Pregnancy
  • Postpartum Hemorrhage
  • Oxytocin
  • Oxytocics
  • Obstetrics & Reproductive Medicine
  • Logistic Models
  • Humans
  • Hematocrit
  • Female