Oxytocin exposure during labor among women with postpartum hemorrhage secondary to uterine atony.

Published

Journal Article

OBJECTIVE: We sought to determine if women with severe postpartum hemorrhage (PPH) secondary to uterine atony received greater amounts of oxytocin during labor compared to women without PPH. STUDY DESIGN: Subjects with severe PPH secondary to uterine atony, who received a blood transfusion, were compared to matched controls. Total oxytocin exposure was calculated as the area under the concentration curve (mU/min*min). Variables were compared using paired t test, χ², and logistic regression. RESULTS: Women with severe PPH had a mean oxytocin area under the curve of 10,054 mU compared to 3762 mU in controls (P < .001). After controlling for race, body mass index, admission hematocrit, induction status, magnesium therapy, and chorioamnionitis using logistic regression, oxytocin area under the curve continued to predict severe PPH. CONCLUSION: Women with severe PPH secondary to uterine atony were exposed to significantly more oxytocin during labor compared to matched controls.

Full Text

Duke Authors

Cited Authors

  • Grotegut, CA; Paglia, MJ; Johnson, LNC; Thames, B; James, AH

Published Date

  • January 2011

Published In

Volume / Issue

  • 204 / 1

Start / End Page

  • 56.e1 - 56.e6

PubMed ID

  • 21047614

Pubmed Central ID

  • 21047614

Electronic International Standard Serial Number (EISSN)

  • 1097-6868

Digital Object Identifier (DOI)

  • 10.1016/j.ajog.2010.08.023

Language

  • eng

Conference Location

  • United States