Semiautomated quantification of the mass and distribution of vascular calcification with multidetector CT: method and evaluation.


Journal Article

Institutional review board approval was obtained for this HIPAA-compliant study. Informed consent was obtained for prospective evaluation in 21 asymptomatic volunteers (10 women, 11 men; mean age, 60 years) but waived for retrospective (10 patients with and five patients without disease) evaluation. Prospective validation was in phantoms. Quantification of mass and calcium distribution was performed with fast semiautomated method, without calibration. For actual versus measured mass in phantoms, R(2) was 0.98; absolute and percentage errors were 1.2 mg and 9.1%, respectively. In asymptomatic volunteers, mean interscan variability for calcium mass quantification in extracoronary arteries was 24.9 mg; mean was 991 units for Agatston scoring. In coronary arteries, mean variability was 5.5 mg; mean Agatston variability was 27.7 units. At retrospective computed tomography, mean total calcified mass was 321.3 mg. Accurate quantification of mass and distribution of calcification in simulated arteries with this method can be applied in vivo, with low interscan variability.

Full Text

Duke Authors

Cited Authors

  • Raman, R; Raman, B; Napel, S; Rubin, GD

Published Date

  • April 2008

Published In

Volume / Issue

  • 247 / 1

Start / End Page

  • 241 - 250

PubMed ID

  • 18292472

Pubmed Central ID

  • 18292472

Electronic International Standard Serial Number (EISSN)

  • 1527-1315

Digital Object Identifier (DOI)

  • 10.1148/radiol.2471062190


  • eng

Conference Location

  • United States