Skip to main content
Journal cover image

MRI of pulmonary embolism using Gd-DTPA-polyethylene glycol polymer enhanced 3D fast gradient echo technique in a canine model.

Publication ,  Journal Article
Li, KC; Pelc, LR; Napel, SA; Goris, ML; Lin, DT; Song, CK; Leung, AN; Rubin, GD; Hollett, MD; Harris, DP
Published in: Magn Reson Imaging
1997

This study was to evaluate the accuracy of MR angiography (MRA) using a Gd-DTPA-polyethylene glycol polymer (Gd-DTPA-PEG) with a 3D fast gradient echo (3D fgre) technique in diagnosing pulmonary embolism in a canine model. Pulmonary emboli were created in six mongrel dogs (20-30 kg) by injecting tantalum oxide-doped autologous blood clots into the femoral veins via cutdowns. MRI was performed with a 1.5 T GE Signa imager using a 3D fgre sequence (11.9/2.3/15 degrees) following intravenous injection of 0.06 mmol Gd/kg of Gd-DTPA-PEG. The dogs were euthanized and spiral CT of the lungs were then obtained on the deceased dogs. The MRI images were reviewed independently and receiver-operating-characteristic (ROC) curves were used for statistical analysis using spiral CT results as the gold standard. The pulmonary emboli were well visualized on spiral CT. Out of 108 pulmonary segments in the six dogs, 24 contained emboli >2 mm and 27 contained emboli < or = 2 mm. With unblinded review, MRI detected 79% of emboli >2 mm and only 48% of emboli < or = 2 mm. The blinded review results were significantly worse. Gd-DTPA-PEG enhanced 3D fgre MRI is potentially able to demonstrate pulmonary embolism with fairly high degree of accuracy, but specialized training for the interpretations will be required.

Duke Scholars

Published In

Magn Reson Imaging

DOI

ISSN

0730-725X

Publication Date

1997

Volume

15

Issue

5

Start / End Page

543 / 550

Location

Netherlands

Related Subject Headings

  • Tomography, X-Ray Computed
  • ROC Curve
  • Pulmonary Embolism
  • Polyethylene Glycols
  • Pentetic Acid
  • Nuclear Medicine & Medical Imaging
  • Magnetic Resonance Angiography
  • Gadolinium DTPA
  • Dogs
  • Contrast Media
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Li, K. C., Pelc, L. R., Napel, S. A., Goris, M. L., Lin, D. T., Song, C. K., … Harris, D. P. (1997). MRI of pulmonary embolism using Gd-DTPA-polyethylene glycol polymer enhanced 3D fast gradient echo technique in a canine model. Magn Reson Imaging, 15(5), 543–550. https://doi.org/10.1016/s0730-725x(97)00001-5
Li, K. C., L. R. Pelc, S. A. Napel, M. L. Goris, D. T. Lin, C. K. Song, A. N. Leung, G. D. Rubin, M. D. Hollett, and D. P. Harris. “MRI of pulmonary embolism using Gd-DTPA-polyethylene glycol polymer enhanced 3D fast gradient echo technique in a canine model.Magn Reson Imaging 15, no. 5 (1997): 543–50. https://doi.org/10.1016/s0730-725x(97)00001-5.
Li KC, Pelc LR, Napel SA, Goris ML, Lin DT, Song CK, et al. MRI of pulmonary embolism using Gd-DTPA-polyethylene glycol polymer enhanced 3D fast gradient echo technique in a canine model. Magn Reson Imaging. 1997;15(5):543–50.
Li, K. C., et al. “MRI of pulmonary embolism using Gd-DTPA-polyethylene glycol polymer enhanced 3D fast gradient echo technique in a canine model.Magn Reson Imaging, vol. 15, no. 5, 1997, pp. 543–50. Pubmed, doi:10.1016/s0730-725x(97)00001-5.
Li KC, Pelc LR, Napel SA, Goris ML, Lin DT, Song CK, Leung AN, Rubin GD, Hollett MD, Harris DP. MRI of pulmonary embolism using Gd-DTPA-polyethylene glycol polymer enhanced 3D fast gradient echo technique in a canine model. Magn Reson Imaging. 1997;15(5):543–550.
Journal cover image

Published In

Magn Reson Imaging

DOI

ISSN

0730-725X

Publication Date

1997

Volume

15

Issue

5

Start / End Page

543 / 550

Location

Netherlands

Related Subject Headings

  • Tomography, X-Ray Computed
  • ROC Curve
  • Pulmonary Embolism
  • Polyethylene Glycols
  • Pentetic Acid
  • Nuclear Medicine & Medical Imaging
  • Magnetic Resonance Angiography
  • Gadolinium DTPA
  • Dogs
  • Contrast Media