Functional computed tomography imaging of tumor-induced angiogenesis: preliminary results of new tracer kinetic modeling using a computer discretization approach.

Journal Article (Journal Article)

PURPOSE: The aim of this study was to establish functional computed tomography (CT) imaging as a method for assessing tumor-induced angiogenesis. MATERIALS AND METHODS: Functional CT imaging was mathematically analyzed for 14 renal cell carcinomas by means of two-compartment modeling using a computer-discretization approach. The model incorporated diffusible kinetics of contrast medium including leakage from the capillary to the extravascular compartment and back-flux to the capillary compartment. The correlations between functional CT parameters [relative blood volume (rbv), permeability 1 (Pm1), and permeability 2 (Pm2)] and histopathological markers of angiogenesis [microvessel density (MVD) and vascular endothelial growth factor (VEGF)] were statistically analyzed. RESULTS: The modeling was successfully performed, showing similarity between the mathematically simulated curve and the measured time-density curve. There were significant linear correlations between MVD grade and Pm1 (r = 0.841, P = 0.001) and between VEGF grade and Pm2 (r = 0.804, P = 0.005) by Pearson's correlation coefficient. CONCLUSION: This method may be a useful tool for the assessment of tumor-induced angiogenesis.

Full Text

Duke Authors

Cited Authors

  • Kaneoya, K; Ueda, T; Suito, H; Nanazawa, Y; Tamaru, J; Isobe, K; Naya, Y; Tobe, T; Motoori, K; Yamamoto, S; Rubin, GD; Minami, M; Ito, H

Published Date

  • May 2008

Published In

Volume / Issue

  • 26 / 4

Start / End Page

  • 213 - 221

PubMed ID

  • 18509721

International Standard Serial Number (ISSN)

  • 0288-2043

Digital Object Identifier (DOI)

  • 10.1007/s11604-007-0217-4


  • eng

Conference Location

  • Japan